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2d4r

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{{STRUCTURE_2d4r| PDB=2d4r | SCENE= }}
{{STRUCTURE_2d4r| PDB=2d4r | SCENE= }}
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'''Crystal structure of TTHA0849 from Thermus thermophilus HB8'''
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===Crystal structure of TTHA0849 from Thermus thermophilus HB8===
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==Overview==
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The crystal structure of a conserved hypothetical protein, TTHA0849 from Thermus thermophilus HB8, has been determined at 2.4 A resolution as a part of a structural and functional genomics project on T. thermophilus HB8. The main-chain folding shows a compact alpha+beta motif, forming a hydrophobic cavity in the molecule. A structural similarity search reveals that it resembles those steroidogenic acute regulatory proteins that contain the lipid-transfer (START) domain, even though TTHA0849 shows comparatively weak sequence identity to polyketide cyclases. However, the size of the ligand-binding cavity is distinctly smaller than other START domain-containing proteins, suggesting that it catalyses the transfer of smaller ligand molecules.
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{{ABSTRACT_PUBMED_16511226}}
==About this Structure==
==About this Structure==
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[[Category: Start domain]]
[[Category: Start domain]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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Revision as of 23:45, 27 July 2008

Image:2d4r.png

Template:STRUCTURE 2d4r

Crystal structure of TTHA0849 from Thermus thermophilus HB8

Template:ABSTRACT PUBMED 16511226

About this Structure

2D4R is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Structure of a conserved hypothetical protein, TTHA0849 from Thermus thermophilus HB8, at 2.4 A resolution: a putative member of the StAR-related lipid-transfer (START) domain superfamily., Nakabayashi M, Shibata N, Komori H, Ueda Y, Iino H, Ebihara A, Kuramitsu S, Higuchi Y, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Dec 1;61(Pt, 12):1027-31. Epub 2005 Nov 5. PMID:16511226

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