3cig

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{{STRUCTURE_3cig| PDB=3cig | SCENE= }}
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'''Crystal structure of mouse TLR3 ectodomain'''
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===Crystal structure of mouse TLR3 ectodomain===
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==Overview==
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Toll-like receptor 3 (TLR3) recognizes double-stranded RNA (dsRNA), a molecular signature of most viruses, and triggers inflammatory responses that prevent viral spread. TLR3 ectodomains (ECDs) dimerize on oligonucleotides of at least 40 to 50 base pairs in length, the minimal length required for signal transduction. To establish the molecular basis for ligand binding and signaling, we determined the crystal structure of a complex between two mouse TLR3-ECDs and dsRNA at 3.4 angstrom resolution. Each TLR3-ECD binds dsRNA at two sites located at opposite ends of the TLR3 horseshoe, and an intermolecular contact between the two TLR3-ECD C-terminal domains coordinates and stabilizes the dimer. This juxtaposition could mediate downstream signaling by dimerizing the cytoplasmic Toll interleukin-1 receptor (TIR) domains. The overall shape of the TLR3-ECD does not change upon binding to dsRNA.
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==About this Structure==
==About this Structure==
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[[Category: Tlr]]
[[Category: Tlr]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:49:47 2008''

Revision as of 23:49, 27 July 2008

Image:3cig.png

Template:STRUCTURE 3cig

Crystal structure of mouse TLR3 ectodomain

Template:ABSTRACT PUBMED 18420935

About this Structure

3CIG is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of toll-like receptor 3 signaling with double-stranded RNA., Liu L, Botos I, Wang Y, Leonard JN, Shiloach J, Segal DM, Davies DR, Science. 2008 Apr 18;320(5874):379-81. PMID:18420935

Page seeded by OCA on Mon Jul 28 02:49:47 2008

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