2vok

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{{STRUCTURE_2vok| PDB=2vok | SCENE= }}
{{STRUCTURE_2vok| PDB=2vok | SCENE= }}
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'''MURINE TRIM21'''
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===MURINE TRIM21===
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==Overview==
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The newly identified tripartite motif (TRIM) family of proteins mediate innate immunity and other critical cellular functions. Here we show that TRIM21, which mediates the autoimmune diseases rheumatoid arthritis, systemic lupus erythematosus, and Sjogren's syndrome, is a previously undescribed IgG receptor with a binding mechanism unlike known mammalian Fcgamma receptors. TRIM21 simultaneously targets conserved hot-spot residues on both Ig domains of the Fc fragment using a PRYSPRY domain with a preformed multisite interface. The binding sites on both TRIM21 and Fc are highly conserved to the extent that the proteins are functionally interchangeable through murine, canine, primate, and human species. Pre-steady-state analysis exposes mechanistic conservation at the level of individual residues, which make the same energetic and kinetic contributions to binding despite varying in sequence. Together, our results reveal that TRIM21 is a previously undescribed type of IgG receptor based on a non-Ig scaffold whose interaction at the fundamental level-structural, thermodynamic, and kinetic-is evolutionarily conserved.
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(as it appears on PubMed at http://www.pubmed.gov), where 18420815 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18420815}}
==About this Structure==
==About this Structure==
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 7 08:54:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:51:24 2008''

Revision as of 23:51, 27 July 2008

Image:2vok.png

Template:STRUCTURE 2vok

MURINE TRIM21

Template:ABSTRACT PUBMED 18420815

About this Structure

2VOK is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved., Keeble AH, Khan Z, Forster A, James LC, Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6045-50. Epub 2008 Apr 17. PMID:18420815

Page seeded by OCA on Mon Jul 28 02:51:24 2008

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