3c21

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_3c21", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
Line 1: Line 1:
-
[[Image:3c21.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:3c21.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3c21| PDB=3c21 | SCENE= }}
{{STRUCTURE_3c21| PDB=3c21 | SCENE= }}
-
'''Structure of a bacterial DNA damage sensor protein with reaction product'''
+
===Structure of a bacterial DNA damage sensor protein with reaction product===
-
==Overview==
+
<!--
-
To reveal mechanisms of DNA damage checkpoint initiation, we structurally and biochemically analyzed DisA, a protein that controls a Bacillus subtilis sporulation checkpoint in response to DNA double-strand breaks. We find that DisA forms a large octamer that consists of an array of an uncharacterized type of nucleotide-binding domain along with two DNA-binding regions related to the Holliday junction recognition protein RuvA. Remarkably, the nucleotide-binding domains possess diadenylate cyclase activity. The resulting cyclic diadenosine phosphate, c-di-AMP, is reminiscent but distinct from c-di-GMP, an emerging prokaryotic regulator of complex cellular processes. Diadenylate cyclase activity is unaffected by linear DNA or DNA ends but strongly suppressed by branched nucleic acids such as Holliday junctions. Our data indicate that DisA signals DNA structures that interfere with chromosome segregation via c-di-AMP. Identification of the diadenylate cyclase domain in other eubacterial and archaeal proteins implies a more general role for c-di-AMP in prokaryotes.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18439896}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18439896 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18439896}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Dna repair]]
[[Category: Dna repair]]
[[Category: Dna-binding]]
[[Category: Dna-binding]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 7 08:54:08 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:53:25 2008''

Revision as of 23:53, 27 July 2008

Image:3c21.png

Template:STRUCTURE 3c21

Structure of a bacterial DNA damage sensor protein with reaction product

Template:ABSTRACT PUBMED 18439896

About this Structure

3C21 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates., Witte G, Hartung S, Buttner K, Hopfner KP, Mol Cell. 2008 Apr 25;30(2):167-78. PMID:18439896

Page seeded by OCA on Mon Jul 28 02:53:25 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3c21"
Personal tools