2bhk

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[[Image:2bhk.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2bhk| PDB=2bhk | SCENE= }}
{{STRUCTURE_2bhk| PDB=2bhk | SCENE= }}
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'''CRYSTAL STRUCTURE OF HUMAN GROWTH AND DIFFERENTIATION FACTOR 5 (GDF5)'''
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===CRYSTAL STRUCTURE OF HUMAN GROWTH AND DIFFERENTIATION FACTOR 5 (GDF5)===
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==Overview==
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The crystal structure of human growth differentiation factor 5 (GDF5) was solved at 2.4A resolution. The structure is very similar to the structure of bone morphogenetic factor 7 (BMP7) and consists of two banana-shaped monomers, linked via a disulfide bridge. The crystal packing of GDF5 is the same as the crystal packing of BMP7. This is highly unusual since only 25-30% of the crystal contacts involve identical residues. Analysis of the crystal packing revealed that residues of the type I receptor epitope are binding to residues of the type II receptor-binding epitope. The fact that for both BMP family members the type I and type II receptor-binding sites interact suggests that the complementary sites on the receptors may interact as well, suggesting a way how preformed receptor heterodimers may form, similar to the preformed receptors observed for the erythropoietin receptor and the BMP2 receptors.
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(as it appears on PubMed at http://www.pubmed.gov), where 15752764 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15752764}}
==About this Structure==
==About this Structure==
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[[Category: Hormone-receptor interaction]]
[[Category: Hormone-receptor interaction]]
[[Category: Preformed receptor dimer]]
[[Category: Preformed receptor dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:17:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:57:26 2008''

Revision as of 23:57, 27 July 2008

Image:2bhk.png

Template:STRUCTURE 2bhk

CRYSTAL STRUCTURE OF HUMAN GROWTH AND DIFFERENTIATION FACTOR 5 (GDF5)

Template:ABSTRACT PUBMED 15752764

About this Structure

2BHK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of recombinant human growth and differentiation factor 5: evidence for interaction of the type I and type II receptor-binding sites., Schreuder H, Liesum A, Pohl J, Kruse M, Koyama M, Biochem Biophys Res Commun. 2005 Apr 15;329(3):1076-86. PMID:15752764

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