1z6w

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[[Image:1z6w.gif|left|200px]]
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{{Seed}}
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[[Image:1z6w.png|left|200px]]
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{{STRUCTURE_1z6w| PDB=1z6w | SCENE= }}
{{STRUCTURE_1z6w| PDB=1z6w | SCENE= }}
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'''Human Lactoferricin'''
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===Human Lactoferricin===
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==Overview==
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Lactoferricins are highly basic bioactive peptides that are released in the stomach through proteolytic cleavage of various lactoferrin proteins. Here we have determined the solution structure of human lactoferricin (LfcinH) by conventional two-dimensional nuclear magnetic resonance methods in both aqueous solution and a membrane mimetic solvent. Unlike the 25-residue bovine lactoferricin (LfcinB), which adopts a somewhat distorted antiparallel beta sheet, the longer LfcinH peptide shows a helical content from Gln14 to Lys29 in the membrane mimetic solvent but a nonexistent beta-sheet character in either the N- or C-terminal regions of the peptide. The helical characteristic of the LfcinH peptide resembles the conformation that this region adopts in the crystal structure of the intact protein. The LfcinH structure determined in aqueous solution displays a nascent helix in the form of a coiled conformation in the region from Gln14 to Lys29. Numerous hydrophobic interactions create the basis for the better-defined overall structure observed in the membrane mimetic solvent. The 49-residue LfcinH peptide isolated for these studies was found to be slightly longer than previously reported peptide preparations and was found to have an intact peptide bond between residues Ala11 and Val12. The distinct solution structures of LfcinH and LfcinB represent a novel difference in the physical properties of these two peptides, which contributes to their unique physiological activities.
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The line below this paragraph, {{ABSTRACT_PUBMED_16048952}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16048952 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16048952}}
==About this Structure==
==About this Structure==
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1Z6W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6W OCA].
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1Z6W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6W OCA].
==Reference==
==Reference==
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[[Category: Aqueous]]
[[Category: Aqueous]]
[[Category: Helical]]
[[Category: Helical]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:15:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:02:44 2008''

Revision as of 00:02, 28 July 2008

Image:1z6w.png

Template:STRUCTURE 1z6w

Human Lactoferricin

Template:ABSTRACT PUBMED 16048952

About this Structure

1Z6W is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Human lactoferricin is partially folded in aqueous solution and is better stabilized in a membrane mimetic solvent., Hunter HN, Demcoe AR, Jenssen H, Gutteberg TJ, Vogel HJ, Antimicrob Agents Chemother. 2005 Aug;49(8):3387-95. PMID:16048952

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