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1pk1

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[[Image:1pk1.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1pk1| PDB=1pk1 | SCENE= }}
{{STRUCTURE_1pk1| PDB=1pk1 | SCENE= }}
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'''Hetero SAM domain structure of Ph and Scm.'''
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===Hetero SAM domain structure of Ph and Scm.===
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==Overview==
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The polycomb group proteins are required for the stable maintenance of gene repression patterns established during development. They function as part of large multiprotein complexes created via a multitude of protein-protein interaction domains. Here we examine the interaction between the SAM domains of the polycomb group proteins polyhomeotic (Ph) and Sex-comb-on-midleg (Scm). Previously we showed that Ph-SAM polymerizes as a helical structure. We find that Scm-SAM also polymerizes, and a crystal structure reveals an architecture similar to the Ph-SAM polymer. These results suggest that Ph-SAM and Scm-SAM form a copolymer. Binding affinity measurements between Scm-SAM and Ph-SAM subunits in different orientations indicate a preference for the formation of a single junction copolymer. To provide a model of the copolymer, we determined the structure of the Ph-SAM/Scm-SAM junction. Similar binding modes are observed in both homo- and heterocomplex formation with minimal change in helix axis direction at the polymer joint. The copolymer model suggests that polymeric Scm complexes could extend beyond the local domains of polymeric Ph complexes on chromatin, possibly playing a role in long range repression.
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The line below this paragraph, {{ABSTRACT_PUBMED_15905166}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15905166 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15905166}}
==About this Structure==
==About this Structure==
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[[Category: Polymer]]
[[Category: Polymer]]
[[Category: Transcriptional repression]]
[[Category: Transcriptional repression]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:10:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:02:50 2008''

Revision as of 00:02, 28 July 2008

Image:1pk1.png

Template:STRUCTURE 1pk1

Hetero SAM domain structure of Ph and Scm.

Template:ABSTRACT PUBMED 15905166

About this Structure

1PK1 is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structural organization of a Sex-comb-on-midleg/polyhomeotic copolymer., Kim CA, Sawaya MR, Cascio D, Kim W, Bowie JU, J Biol Chem. 2005 Jul 29;280(30):27769-75. Epub 2005 May 19. PMID:15905166

Page seeded by OCA on Mon Jul 28 03:02:50 2008

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