2ivn

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{{STRUCTURE_2ivn| PDB=2ivn | SCENE= }}
{{STRUCTURE_2ivn| PDB=2ivn | SCENE= }}
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'''STRUCTURE OF UP1 PROTEIN'''
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===STRUCTURE OF UP1 PROTEIN===
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==Overview==
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The Kae1 (Kinase-associated endopeptidase 1) protein is a member of the recently identified transcription complex EKC and telomeres maintenance complex KEOPS in yeast. Kae1 homologues are encoded by all sequenced genomes in the three domains of life. Although annotated as putative endopeptidases, the actual functions of these universal proteins are unknown. Here we show that the purified Kae1 protein (Pa-Kae1) from Pyrococcus abyssi is an iron-protein with a novel type of ATP-binding site. Surprisingly, this protein did not exhibit endopeptidase activity in vitro but binds cooperatively to single and double-stranded DNA and induces unusual DNA conformational change. Furthermore, Pa-Kae1 exhibits a class I apurinic (AP)-endonuclease activity (AP-lyase). Both DNA binding and AP-endonuclease activity are inhibited by ATP. Kae1 is thus a novel and atypical universal DNA interacting protein whose importance could rival those of RecA (RadA/Rad51) in the maintenance of genome integrity in all living cells.
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{{ABSTRACT_PUBMED_17766251}}
==About this Structure==
==About this Structure==
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[[Category: Up1 keops complex]]
[[Category: Up1 keops complex]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:56:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:04:25 2008''

Revision as of 00:04, 28 July 2008

Image:2ivn.png

Template:STRUCTURE 2ivn

STRUCTURE OF UP1 PROTEIN

Template:ABSTRACT PUBMED 17766251

About this Structure

2IVN is a Single protein structure of sequence from Pyrococcus abyssi. Full crystallographic information is available from OCA.

Reference

An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro., Hecker A, Leulliot N, Gadelle D, Graille M, Justome A, Dorlet P, Brochier C, Quevillon-Cheruel S, Le Cam E, van Tilbeurgh H, Forterre P, Nucleic Acids Res. 2007;35(18):6042-51. Epub 2007 Aug 30. PMID:17766251

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