1qbh

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{{STRUCTURE_1qbh| PDB=1qbh | SCENE= }}
{{STRUCTURE_1qbh| PDB=1qbh | SCENE= }}
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'''SOLUTION STRUCTURE OF A BACULOVIRAL INHIBITOR OF APOPTOSIS (IAP) REPEAT'''
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===SOLUTION STRUCTURE OF A BACULOVIRAL INHIBITOR OF APOPTOSIS (IAP) REPEAT===
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==Overview==
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Members of the inhibitor of apoptosis (IAP) family of proteins are able to inhibit cell death following viral infection, during development or in cell lines in vitro. All IAP proteins bear one or more baculoviral IAP repeats (BIRs). Here we describe the solution structure of the third BIR domain from the mammalian IAP homolog B (MIHB/c-IAP-1). The BIR domain has a novel fold that is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues. The structure consists of a series of short alpha-helices and turns with the zinc packed in an unusually hydrophobic environment created by residues that are highly conserved among all BIRs.
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(as it appears on PubMed at http://www.pubmed.gov), where 10404221 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10404221}}
==About this Structure==
==About this Structure==
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1QBH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QBH OCA].
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1QBH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QBH OCA].
==Reference==
==Reference==
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[[Category: Nmr structure]]
[[Category: Nmr structure]]
[[Category: Zinc binding domain]]
[[Category: Zinc binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:06:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:04:42 2008''

Revision as of 00:04, 28 July 2008

Image:1qbh.png

Template:STRUCTURE 1qbh

SOLUTION STRUCTURE OF A BACULOVIRAL INHIBITOR OF APOPTOSIS (IAP) REPEAT

Template:ABSTRACT PUBMED 10404221

About this Structure

1QBH is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat., Hinds MG, Norton RS, Vaux DL, Day CL, Nat Struct Biol. 1999 Jul;6(7):648-51. PMID:10404221

Page seeded by OCA on Mon Jul 28 03:04:42 2008

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