1tve

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[[Image:1tve.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1tve| PDB=1tve | SCENE= }}
{{STRUCTURE_1tve| PDB=1tve | SCENE= }}
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'''Homoserine Dehydrogenase in complex with 4-(4-hydroxy-3-isopropylphenylthio)-2-isopropylphenol'''
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===Homoserine Dehydrogenase in complex with 4-(4-hydroxy-3-isopropylphenylthio)-2-isopropylphenol===
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==Overview==
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A relatively unexploited potential target for antimicrobial agents is the biosynthesis of essential amino acids. Homoserine dehydrogenase, which reduces aspartate semi-aldehyde to homoserine in a NAD(P)H-dependent reaction, is one such target that is required for the biosynthesis of Met, Thr, and Ile from Asp. We report a small molecule screen of yeast homoserine dehydrogenase that has identified a new class of phenolic inhibitors of this class of enzyme. X-ray crystal structural analysis of one of the inhibitors in complex with homoserine dehydrogenase reveals that these molecules bind in the amino acid binding region of the active site and that the phenolic hydroxyl group interacts specifically with the backbone amide of Gly175. These results provide the first nonamino acid inhibitors of this class of enzyme and have the potential to be exploited as leads in antifungal compound design.
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(as it appears on PubMed at http://www.pubmed.gov), where 15210149 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15210149}}
==About this Structure==
==About this Structure==
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[[Category: Antifungal]]
[[Category: Antifungal]]
[[Category: Small molecule screening]]
[[Category: Small molecule screening]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:24:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:08:31 2008''

Revision as of 00:08, 28 July 2008

Image:1tve.png

Template:STRUCTURE 1tve

Homoserine Dehydrogenase in complex with 4-(4-hydroxy-3-isopropylphenylthio)-2-isopropylphenol

Template:ABSTRACT PUBMED 15210149

About this Structure

1TVE is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

New phenolic inhibitors of yeast homoserine dehydrogenase., Ejim L, Mirza IA, Capone C, Nazi I, Jenkins S, Chee GL, Berghuis AM, Wright GD, Bioorg Med Chem. 2004 Jul 15;12(14):3825-30. PMID:15210149

Page seeded by OCA on Mon Jul 28 03:08:31 2008

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