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1p5r

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[[Image:1p5r.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1p5r| PDB=1p5r | SCENE= }}
{{STRUCTURE_1p5r| PDB=1p5r | SCENE= }}
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'''Formyl-CoA Transferase in complex with Coenzyme A'''
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===Formyl-CoA Transferase in complex with Coenzyme A===
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==Overview==
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Formyl-CoA transferase catalyses transfer of CoA from formate to oxalate in the first step of oxalate degradation by Oxalobacter formigenes, a bacterium present in the intestinal flora which is implicated in oxalate catabolism in mammals. Formyl-CoA transferase is a member of a family of CoA-transferases for which no structural information is available. We now report the three-dimensional structure of O.formigenes formyl-CoA transferase, which reveals a novel fold and a very striking assembly of the homodimer. The subunit is composed of a large and a small domain where residues from both the N- and C-termini of the subunit are part of the large domain. The linkers between the domains give the subunit a circular shape with a hole in the middle. The enzyme monomers are tightly interacting and are interlocked. This fold requires drastic rearrangement of approximately 75 residues at the C-terminus for formation of the dimer. The structure of a complex of formyl-CoA transferase with CoA is also reported and sets the scene for a mechanistic understanding of enzymes of this family of CoA-transferases.
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(as it appears on PubMed at http://www.pubmed.gov), where 12839984 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12839984}}
==About this Structure==
==About this Structure==
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[[Category: Oxalate]]
[[Category: Oxalate]]
[[Category: Oxalate degradation]]
[[Category: Oxalate degradation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:43:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:15:31 2008''

Revision as of 00:15, 28 July 2008

Image:1p5r.png

Template:STRUCTURE 1p5r

Formyl-CoA Transferase in complex with Coenzyme A

Template:ABSTRACT PUBMED 12839984

About this Structure

1P5R is a Single protein structure of sequence from Oxalobacter formigenes. Full crystallographic information is available from OCA.

Reference

Formyl-CoA transferase encloses the CoA binding site at the interface of an interlocked dimer., Ricagno S, Jonsson S, Richards N, Lindqvist Y, EMBO J. 2003 Jul 1;22(13):3210-9. PMID:12839984

Page seeded by OCA on Mon Jul 28 03:15:31 2008

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