2v7g

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{{STRUCTURE_2v7g| PDB=2v7g | SCENE= }}
{{STRUCTURE_2v7g| PDB=2v7g | SCENE= }}
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'''CRYSTAL STRUCTURE OF AN ENGINEERED UROCANASE TETRAMER'''
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===CRYSTAL STRUCTURE OF AN ENGINEERED UROCANASE TETRAMER===
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==Overview==
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The analysis of natural contact interfaces between protein subunits and between proteins has disclosed some general rules governing their association. We have applied these rules to produce a number of novel assemblies, demonstrating that a given protein can be engineered to form contacts at various points of its surface. Symmetry plays an important role because it defines the multiplicity of a designed contact and therefore the number of required mutations. Some of the proteins needed only a single side-chain alteration in order to associate to a higher-order complex. The mobility of the buried side chains has to be taken into account. Four assemblies have been structurally elucidated. Comparisons between the designed contacts and the results will provide useful guidelines for the development of future architectures.
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(as it appears on PubMed at http://www.pubmed.gov), where 18187656 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18187656}}
==About this Structure==
==About this Structure==
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[[Category: Protein engineering]]
[[Category: Protein engineering]]
[[Category: Urocanate hydratase]]
[[Category: Urocanate hydratase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:19:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:17:46 2008''

Revision as of 00:17, 28 July 2008

Image:2v7g.png

Template:STRUCTURE 2v7g

CRYSTAL STRUCTURE OF AN ENGINEERED UROCANASE TETRAMER

Template:ABSTRACT PUBMED 18187656

About this Structure

2V7G is a Single protein structure of sequence from Pseudomonas putida. Full crystallographic information is available from OCA.

Reference

Designed protein-protein association., Grueninger D, Treiber N, Ziegler MO, Koetter JW, Schulze MS, Schulz GE, Science. 2008 Jan 11;319(5860):206-9. PMID:18187656

Page seeded by OCA on Mon Jul 28 03:17:46 2008

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