2gcz

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[[Image:2gcz.gif|left|200px]]
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{{Seed}}
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[[Image:2gcz.png|left|200px]]
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{{STRUCTURE_2gcz| PDB=2gcz | SCENE= }}
{{STRUCTURE_2gcz| PDB=2gcz | SCENE= }}
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'''Solution Structure of alpha-Conotoxin OmIA'''
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===Solution Structure of alpha-Conotoxin OmIA===
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==Overview==
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alpha-Conotoxin OmIA from Conus omaria is the only alpha-conotoxin that shows a approximately 20-fold higher affinity to the alpha3beta2 over the alpha6beta2 subtype of nicotinic acetylcholine receptor. We have determined a three-dimensional structure of alpha-conotoxin OmIA by nuclear magnetic resonance spectroscopy. alpha-Conotoxin OmIA has an "omega-shaped" overall topology with His(5)-Asn(12) forming an alpha-helix. Structural features of alpha-conotoxin OmIA responsible for its selectivity are suggested by comparing its surface characteristics with other functionally related alpha4/7 subfamily conotoxins. Reduced size of the hydrophilic area in alpha-conotoxin OmIA seems to be associated with the reduced affinity towards the alpha6beta2 nAChR subtype.
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The line below this paragraph, {{ABSTRACT_PUBMED_16678128}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16678128 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16678128}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCZ OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCZ OCA].
==Reference==
==Reference==
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[[Category: C-terminal amidation]]
[[Category: C-terminal amidation]]
[[Category: Two disulfide bond]]
[[Category: Two disulfide bond]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:57:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:18:26 2008''

Revision as of 00:18, 28 July 2008

Image:2gcz.png

Template:STRUCTURE 2gcz

Solution Structure of alpha-Conotoxin OmIA

Template:ABSTRACT PUBMED 16678128

About this Structure

Full experimental information is available from OCA.

Reference

Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist alpha-conotoxin OmIA that discriminates alpha3 vs. alpha6 nAChR subtypes., Chi SW, Kim DH, Olivera BM, McIntosh JM, Han KH, Biochem Biophys Res Commun. 2006 Jun 23;345(1):248-54. Epub 2006 Apr 27. PMID:16678128

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