2a5e

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[[Image:2a5e.gif|left|200px]]
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{{STRUCTURE_2a5e| PDB=2a5e | SCENE= }}
{{STRUCTURE_2a5e| PDB=2a5e | SCENE= }}
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'''SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, RESTRAINED MINIMIZED MEAN STRUCTURE'''
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===SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, RESTRAINED MINIMIZED MEAN STRUCTURE===
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==Overview==
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The solution structure of the tumor suppressor p16INK4A has been determined by NMR, and important recognition regions of both cdk4 and p16INK4A have been identified. The tertiary structure of p16INK4A contains four helix-turn-helix motifs linked by three loops. Twelve tumorigenic mutants of p16INK4A have been constructed and analyzed for their structure and activity, and new mutants have been designed rationally. A fragment of 58 residues at the N terminus of cdk4 important for p16INK4A binding has been identified. The importance of this region was further verified by mutational analysis of cdk4. These results and docking experiments have been used to assess possible modes of binding between p16INK4A and cdk4.
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The line below this paragraph, {{ABSTRACT_PUBMED_9660926}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9660926 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9660926}}
==About this Structure==
==About this Structure==
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2A5E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5E OCA].
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2A5E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A5E OCA].
==Reference==
==Reference==
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[[Category: Anti-oncogene]]
[[Category: Anti-oncogene]]
[[Category: Tumor-suppressor-p16ink4a]]
[[Category: Tumor-suppressor-p16ink4a]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:37:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:21:32 2008''

Revision as of 00:21, 28 July 2008

Image:2a5e.png

Template:STRUCTURE 2a5e

SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, RESTRAINED MINIMIZED MEAN STRUCTURE

Template:ABSTRACT PUBMED 9660926

About this Structure

2A5E is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4., Byeon IJ, Li J, Ericson K, Selby TL, Tevelev A, Kim HJ, O'Maille P, Tsai MD, Mol Cell. 1998 Feb;1(3):421-31. PMID:9660926

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