2iuk

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[[Image:2iuk.gif|left|200px]]
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{{Seed}}
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[[Image:2iuk.png|left|200px]]
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{{STRUCTURE_2iuk| PDB=2iuk | SCENE= }}
{{STRUCTURE_2iuk| PDB=2iuk | SCENE= }}
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'''CRYSTAL STRUCTURE OF SOYBEAN LIPOXYGENASE-D'''
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===CRYSTAL STRUCTURE OF SOYBEAN LIPOXYGENASE-D===
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==Overview==
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The lipoxygenase family of lipid-peroxidizing, nonheme iron dioxygenases form products that are precursors for diverse physiological processes in both plants and animals. In soybean (Glycine max), five vegetative isoforms, VLX-A, VLX-B, VLX-C, VLX-D, VLX-E, and four seed isoforms LOX-1, LOX-2, LOX-3a, LOX-3b have been identified. In this study, we determined the crystal structures of the substrate-free forms of two major vegetative isoforms, with distinct enzymatic characteristics, VLX-B and VLX-D. Their structures are similar to the two seed isoforms, LOX-1 and LOX-3, having two domains with similar secondary structural elements: a beta-barrel N-terminal domain containing highly flexible loops and an alpha-helix-rich C-terminal catalytic domain. Detailed comparison of the structures of these two vegetative isoforms with the structures of LOX-1 and LOX-3 reveals important differences that help explain distinct aspects of the activity and positional specificity of these enzymes. In particular, the shape of the three branches of the internal subcavity, corresponding to substrate-binding and O(2) access, differs among the isoforms in a manner that reflects the differences in positional specificities.
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The line below this paragraph, {{ABSTRACT_PUBMED_17022084}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17022084 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17022084}}
==About this Structure==
==About this Structure==
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[[Category: Oxylipin biosynthesis]]
[[Category: Oxylipin biosynthesis]]
[[Category: Soybean lipoxygenase-d]]
[[Category: Soybean lipoxygenase-d]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:54:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:24:00 2008''

Revision as of 00:24, 28 July 2008

Image:2iuk.png

Template:STRUCTURE 2iuk

CRYSTAL STRUCTURE OF SOYBEAN LIPOXYGENASE-D

Template:ABSTRACT PUBMED 17022084

About this Structure

2IUK is a Single protein structure of sequence from Glycine max. Full crystallographic information is available from OCA.

Reference

Crystal structures of vegetative soybean lipoxygenase VLX-B and VLX-D, and comparisons with seed isoforms LOX-1 and LOX-3., Youn B, Sellhorn GE, Mirchel RJ, Gaffney BJ, Grimes HD, Kang C, Proteins. 2006 Dec 1;65(4):1008-20. PMID:17022084

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