1oln

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1oln.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1oln.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1oln| PDB=1oln | SCENE= }}
{{STRUCTURE_1oln| PDB=1oln | SCENE= }}
-
'''MODEL FOR THIOSTREPTON ANTIBIOTIC BINDING TO L11 SUBSTRATE FROM 50S RIBOSOMAL RNA'''
+
===MODEL FOR THIOSTREPTON ANTIBIOTIC BINDING TO L11 SUBSTRATE FROM 50S RIBOSOMAL RNA===
-
==Overview==
+
<!--
-
Thiostrepton and micrococcin inhibit protein synthesis by binding to the L11 binding domain (L11BD) of 23S ribosomal RNA. The two compounds are structurally related, yet they produce different effects on ribosomal RNA in footprinting experiments and on elongation factor-G (EF-G)-dependent GTP hydrolysis. Using NMR and an assay based on A1067 methylation by thiostrepton-resistance methyltransferase, we show that the related thiazoles, nosiheptide and siomycin, also bind to this region. The effect of all four antibiotics on EF-G-dependent GTP hydrolysis and EF-G-GDP-ribosome complex formation was studied. Our NMR and biochemical data demonstrate that thiostrepton, nosiheptide, and siomycin share a common profile, which differs from that of micrococcin. We have generated a three-dimensional (3D) model for the interaction of thiostrepton with L11BD RNA. The model rationalizes the differences between micrococcin and the thiostrepton-like antibiotics interacting with L11BD.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12954336}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12954336 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12954336}}
==About this Structure==
==About this Structure==
-
1OLN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLN OCA].
+
1OLN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLN OCA].
==Reference==
==Reference==
Line 35: Line 39:
[[Category: Thiostrepton]]
[[Category: Thiostrepton]]
[[Category: Translation inhibition]]
[[Category: Translation inhibition]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:00:07 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:34:14 2008''

Revision as of 00:34, 28 July 2008

Image:1oln.png

Template:STRUCTURE 1oln

MODEL FOR THIOSTREPTON ANTIBIOTIC BINDING TO L11 SUBSTRATE FROM 50S RIBOSOMAL RNA

Template:ABSTRACT PUBMED 12954336

About this Structure

1OLN is a Protein complex structure of sequences from Thermotoga maritima. Full experimental information is available from OCA.

Reference

Structural basis for contrasting activities of ribosome binding thiazole antibiotics., Lentzen G, Klinck R, Matassova N, Aboul-ela F, Murchie AI, Chem Biol. 2003 Aug;10(8):769-78. PMID:12954336

Page seeded by OCA on Mon Jul 28 03:34:14 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1oln"
Personal tools