This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.




2an2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2an2.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2an2.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2an2| PDB=2an2 | SCENE= }}
{{STRUCTURE_2an2| PDB=2an2 | SCENE= }}
-
'''P332G, A333S Double mutant of the Bacillus subtilis Nitric Oxide Synthase'''
+
===P332G, A333S Double mutant of the Bacillus subtilis Nitric Oxide Synthase===
-
==Overview==
+
<!--
-
Cooperativity among ligand binding, subunit association, and protein folding has implications for enzyme regulation as well as protein aggregation events associated with disease. The binding of substrate l-arginine or cofactor tetrahydrobiopterin converts nitric oxide synthases (NOSs) from a "loose dimer", with an exposed active center and higher sensitivity to proteolysis, to a "tight dimer" competent for catalysis. The crystallographic structure of the Bacillus subtilis NOS loose dimer shows an altered association state with severely destabilized subdomains. Ligand binding or heme reduction converts loose dimers to tight dimers in solution and crystals. Mutations at key positions in the dimer interface that distinguish prokaryotic from eukaryotic NOSs affect the propensity to form loose dimers. The loose dimer structure indicates that non-native interactions can mediate subunit association in NOS.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16126221}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16126221 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16126221}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Pant, K.]]
[[Category: Pant, K.]]
[[Category: Double mutant]]
[[Category: Double mutant]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:14:24 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:36:18 2008''

Revision as of 00:36, 28 July 2008

Image:2an2.png

Template:STRUCTURE 2an2

P332G, A333S Double mutant of the Bacillus subtilis Nitric Oxide Synthase

Template:ABSTRACT PUBMED 16126221

About this Structure

2AN2 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Structure of a loose dimer: an intermediate in nitric oxide synthase assembly., Pant K, Crane BR, J Mol Biol. 2005 Sep 30;352(4):932-40. PMID:16126221

Page seeded by OCA on Mon Jul 28 03:36:18 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2an2"
Personal tools