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1u3n

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[[Image:1u3n.gif|left|200px]]
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[[Image:1u3n.png|left|200px]]
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{{STRUCTURE_1u3n| PDB=1u3n | SCENE= }}
{{STRUCTURE_1u3n| PDB=1u3n | SCENE= }}
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'''A SOD-like protein from B. subtilis, unstructured in solution, becomes ordered in the crystal: implications for function and for fibrillogenesis'''
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===A SOD-like protein from B. subtilis, unstructured in solution, becomes ordered in the crystal: implications for function and for fibrillogenesis===
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==Overview==
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Little is known about prokaryotic homologs of Cu,Zn superoxide dismutase (SOD), an enzyme highly conserved among eukaryotic species. In 138 Archaea and Bacteria genomes, 57 of these putative homologs were found, 11 of which lack at least one of the metal ligands. Both the solution and the crystal structures of the SOD-like protein from Bacillus subtilis, lacking two Cu ligands and found to be enzymatically inactive, were determined. In solution, the protein is monomeric. The available nuclear Overhauser effects, together with chemical-shift index values, allowed us to define and to recognize the typical Cu,Zn SOD Greek beta-barrel but with largely unstructured loops (which, therefore, sample a wide range of conformations). On the contrary, in the crystal structure (obtained in the presence of slight excess of Zn), the protein is well structured and organized in covalent dimers held by a symmetric bridge consisting of a Zn ion bound to an Asp-His dyad in a tetrahedral geometry. Couples of dimers held by hydrophobic interactions and H bonds are further organized in long chains. The order/disorder transition is discussed in terms of metal binding and physical state.
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The line below this paragraph, {{ABSTRACT_PUBMED_15897454}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15897454 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15897454}}
==About this Structure==
==About this Structure==
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1U3N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3N OCA].
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1U3N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U3N OCA].
==Reference==
==Reference==
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[[Category: Sod-like]]
[[Category: Sod-like]]
[[Category: Solution structure]]
[[Category: Solution structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:43:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:37:50 2008''

Revision as of 00:37, 28 July 2008

Image:1u3n.png

Template:STRUCTURE 1u3n

A SOD-like protein from B. subtilis, unstructured in solution, becomes ordered in the crystal: implications for function and for fibrillogenesis

Template:ABSTRACT PUBMED 15897454

About this Structure

1U3N is a Single protein structure of sequence from Bacillus subtilis. Full experimental information is available from OCA.

Reference

A prokaryotic superoxide dismutase paralog lacking two Cu ligands: from largely unstructured in solution to ordered in the crystal., Banci L, Bertini I, Calderone V, Cramaro F, Del Conte R, Fantoni A, Mangani S, Quattrone A, Viezzoli MS, Proc Natl Acad Sci U S A. 2005 May 24;102(21):7541-6. Epub 2005 May 16. PMID:15897454

Page seeded by OCA on Mon Jul 28 03:37:50 2008

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