2bbx

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{{STRUCTURE_2bbx| PDB=2bbx | SCENE= }}
{{STRUCTURE_2bbx| PDB=2bbx | SCENE= }}
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'''NMR solution structure of the TSR domain of malaria TRAP protein'''
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===NMR solution structure of the TSR domain of malaria TRAP protein===
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==Overview==
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Thrombospondin-related anonymous protein, TRAP, has a critical role in the hepatocyte invasion step of Plasmodium sporozoites, the transmissible form of the parasite causing malaria. The extracellular domains of this sporozoite surface protein interact with hepatocyte surface receptors whereas its intracellular domain acts as a link to the sporozoite actomyosin motor system. Liver heparan sulfate proteoglycans have been identified as potential ligands for TRAP. Proteoglycan binding has been associated with the A- and TSR domains of TRAP. We present the solution NMR structure of the TSR domain of TRAP and a chemical shift mapping study of its heparin binding epitope. The domain has an elongated structure stabilized by an array of tryptophan and arginine residues as well as disulfide bonds. The fold is very similar to those of thrombospondin type-1 (TSP-1) and F-spondin TSRs. The heparin binding site of TRAP-TSR is located in the N-terminal half of the structure, the layered side chains forming an integral part of the site. The smallest heparin fragment capable of binding to TRAP-TSR is a tetrasaccharide.
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(as it appears on PubMed at http://www.pubmed.gov), where 16815922 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16815922}}
==About this Structure==
==About this Structure==
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2BBX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA].
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2BBX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBX OCA].
==Reference==
==Reference==
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[[Category: Tossavainen, H.]]
[[Category: Tossavainen, H.]]
[[Category: Elongated three-stranded structure]]
[[Category: Elongated three-stranded structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:05:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:41:03 2008''

Revision as of 00:41, 28 July 2008

Image:2bbx.png

Template:STRUCTURE 2bbx

NMR solution structure of the TSR domain of malaria TRAP protein

Template:ABSTRACT PUBMED 16815922

About this Structure

2BBX is a Single protein structure of sequence from Plasmodium falciparum. Full experimental information is available from OCA.

Reference

The layered fold of the TSR domain of P. falciparum TRAP contains a heparin binding site., Tossavainen H, Pihlajamaa T, Huttunen TK, Raulo E, Rauvala H, Permi P, Kilpelainen I, Protein Sci. 2006 Jul;15(7):1760-8. PMID:16815922

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