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2nwx

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[[Image:2nwx.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2nwx| PDB=2nwx | SCENE= }}
{{STRUCTURE_2nwx| PDB=2nwx | SCENE= }}
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'''Crystal structure of GltPh in complex with L-aspartate and sodium ions'''
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===Crystal structure of GltPh in complex with L-aspartate and sodium ions===
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==Overview==
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Secondary transporters are integral membrane proteins that catalyse the movement of substrate molecules across the lipid bilayer by coupling substrate transport to one or more ion gradients, thereby providing a mechanism for the concentrative uptake of substrates. Here we describe crystallographic and thermodynamic studies of Glt(Ph), a sodium (Na+)-coupled aspartate transporter, defining sites for aspartate, two sodium ions and d,l-threo-beta-benzyloxyaspartate, an inhibitor. We further show that helical hairpin 2 is the extracellular gate that controls access of substrate and ions to the internal binding sites. At least two sodium ions bind in close proximity to the substrate and these sodium-binding sites, together with the sodium-binding sites in another sodium-coupled transporter, LeuT, define an unwound alpha-helix as the central element of the ion-binding motif, a motif well suited to the binding of sodium and to participation in conformational changes that accompany ion binding and unbinding during the transport cycle.
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The line below this paragraph, {{ABSTRACT_PUBMED_17230192}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17230192 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17230192}}
==About this Structure==
==About this Structure==
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[[Category: Substrate binding]]
[[Category: Substrate binding]]
[[Category: Transmembrane transporter]]
[[Category: Transmembrane transporter]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:00:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:42:23 2008''

Revision as of 00:42, 28 July 2008

Image:2nwx.png

Template:STRUCTURE 2nwx

Crystal structure of GltPh in complex with L-aspartate and sodium ions

Template:ABSTRACT PUBMED 17230192

About this Structure

2NWX is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter., Boudker O, Ryan RM, Yernool D, Shimamoto K, Gouaux E, Nature. 2007 Jan 25;445(7126):387-93. Epub 2007 Jan 17. PMID:17230192

Page seeded by OCA on Mon Jul 28 03:42:23 2008

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