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1rke

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[[Image:1rke.gif|left|200px]]
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{{STRUCTURE_1rke| PDB=1rke | SCENE= }}
{{STRUCTURE_1rke| PDB=1rke | SCENE= }}
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'''Human vinculin head (1-258) in complex with human vinculin tail (879-1066)'''
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===Human vinculin head (1-258) in complex with human vinculin tail (879-1066)===
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==Overview==
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Vinculin is a conserved component and an essential regulator of both cell-cell (cadherin-mediated) and cell-matrix (integrin-talin-mediated focal adhesions) junctions, and it anchors these adhesion complexes to the actin cytoskeleton by binding to talin in integrin complexes or to alpha-actinin in cadherin junctions. In its resting state, vinculin is held in a closed conformation through interactions between its head (Vh) and tail (Vt) domains. The binding of vinculin to focal adhesions requires its association with talin. Here we report the crystal structures of human vinculin in its inactive and talin-activated states. Talin binding induces marked conformational changes in Vh, creating a novel helical bundle structure, and this alteration actively displaces Vt from Vh. These results, as well as the ability of alpha-actinin to also bind to Vh and displace Vt from pre-existing Vh-Vt complexes, support a model whereby Vh functions as a domain that undergoes marked structural changes that allow vinculin to direct cytoskeletal assembly in focal adhesions and adherens junctions. Notably, talin's effects on Vh structure establish helical bundle conversion as a signalling mechanism by which proteins direct cellular responses.
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The line below this paragraph, {{ABSTRACT_PUBMED_14702644}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14702644 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14702644}}
==Disease==
==Disease==
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[[Category: Cytoskeleton]]
[[Category: Cytoskeleton]]
[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:36:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:44:02 2008''

Revision as of 00:44, 28 July 2008

Image:1rke.png

Template:STRUCTURE 1rke

Contents

Human vinculin head (1-258) in complex with human vinculin tail (879-1066)

Template:ABSTRACT PUBMED 14702644

Disease

Known disease associated with this structure: Cardiomyopathy, dilated, 1W OMIM:[193065]

About this Structure

1RKE is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Vinculin activation by talin through helical bundle conversion., Izard T, Evans G, Borgon RA, Rush CL, Bricogne G, Bois PR, Nature. 2004 Jan 8;427(6970):171-5. Epub 2003 Dec 31. PMID:14702644

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