2nnu

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[[Image:2nnu.gif|left|200px]]
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{{STRUCTURE_2nnu| PDB=2nnu | SCENE= }}
{{STRUCTURE_2nnu| PDB=2nnu | SCENE= }}
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'''Crystal Structure of the Papillomavirus DNA Tethering Complex E2:Brd4'''
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===Crystal Structure of the Papillomavirus DNA Tethering Complex E2:Brd4===
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==Overview==
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Many DNA viruses that are latent in dividing cells are noncovalent passengers on mitotic chromosomes and require specific viral-encoded and cellular factors for this activity. The chromosomal protein Brd4 is implicated in the hitchhiking of bovine papillomavirus-1 (BPV-1), and the viral protein E2 binds to both plasmids and Brd4. Here, we present the X-ray crystal structure of the carboxy-terminal domain of Brd4 in complex with HPV-16 E2, and with this information have developed a Brd4-Tat fusion protein that is efficiently taken up by different transformed cells harboring HPV plasmids. In cells treated with these fusion proteins for only 2 hr and arrested in metaphase, the HPV DNA, either HPV-16 or -31, is displaced from mitotic chromosomes. Mutant Brd4 peptides are deficient in ablating this association. We suggest that such peptides may lead to the development of inhibitors of latency for many, if not all, papillomaviruses.
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The line below this paragraph, {{ABSTRACT_PUBMED_17189190}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17189190 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17189190}}
==About this Structure==
==About this Structure==
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[[Category: Protein-peptide complex]]
[[Category: Protein-peptide complex]]
[[Category: Three helix bundle]]
[[Category: Three helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:41:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:44:24 2008''

Revision as of 00:44, 28 July 2008

Image:2nnu.png

Template:STRUCTURE 2nnu

Crystal Structure of the Papillomavirus DNA Tethering Complex E2:Brd4

Template:ABSTRACT PUBMED 17189190

About this Structure

2NNU is a Protein complex structure of sequences from Homo sapiens and Human papillomavirus type 16. Full crystallographic information is available from OCA.

Reference

Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association., Abbate EA, Voitenleitner C, Botchan MR, Mol Cell. 2006 Dec 28;24(6):877-89. PMID:17189190

Page seeded by OCA on Mon Jul 28 03:44:24 2008

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