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1p9f

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[[Image:1p9f.jpg|left|200px]]
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{{STRUCTURE_1p9f| PDB=1p9f | SCENE= }}
{{STRUCTURE_1p9f| PDB=1p9f | SCENE= }}
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'''NMR Structure of Neurokinin B from DYANA'''
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===NMR Structure of Neurokinin B from DYANA===
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==Overview==
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Neurokinin B (NKB), a decapeptide of mammalian origin exhibits a variety of biological activities such as regulatory functions in reproduction, pre-eclampsia and neuroprotection in Alzheimer's disease. In order to gain insight into structure-function relationship, three-dimensional structure of NKB has been investigated using CD spectropolarimetry and two-dimensional proton nuclear magnetic resonance (2D 1H-NMR) spectroscopy in aqueous and membrane mimetic solvents. Unambiguous NMR assignments of resonances have been made with the aid of correlation spectroscopy (DQF-COSY and TOCSY) experiments and Nuclear Overhauser Effect Spectroscopy (NOESY) experiments. Distance constraints obtained from the NMR data have been used to generate a family of structures, which have been refined using restrained energy minimization and dynamics. Our data show that a helical structure is induced in NKB, in presence of perdeuterated dodecyl phosphocholine (DPC) micelles, a membrane model system. Further, the conformation adopted by NKB in presence of DPC micelles represents a structural motif typical of neurokinin-3 selective agonists.
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(as it appears on PubMed at http://www.pubmed.gov), where 15317475 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15317475}}
==About this Structure==
==About this Structure==
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1P9F is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9F OCA].
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1P9F is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9F OCA].
==Reference==
==Reference==
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[[Category: Protein]]
[[Category: Protein]]
[[Category: Structures from dyana]]
[[Category: Structures from dyana]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:50:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:45:43 2008''

Revision as of 00:45, 28 July 2008

Image:1p9f.png

Template:STRUCTURE 1p9f

NMR Structure of Neurokinin B from DYANA

Template:ABSTRACT PUBMED 15317475

About this Structure

1P9F is a Single protein structure. Full experimental information is available from OCA.

Reference

Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles., Mantha AK, Chandrashekar IR, Baquer NZ, Cowsik SM, J Biomol Struct Dyn. 2004 Oct;22(2):137-48. PMID:15317475

Page seeded by OCA on Mon Jul 28 03:45:43 2008

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