1vrl

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[[Image:1vrl.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1vrl| PDB=1vrl | SCENE= }}
{{STRUCTURE_1vrl| PDB=1vrl | SCENE= }}
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'''MutY adenine glycosylase in complex with DNA and soaked adenine free base'''
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===MutY adenine glycosylase in complex with DNA and soaked adenine free base===
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==Overview==
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The genomes of aerobic organisms suffer chronic oxidation of guanine to the genotoxic product 8-oxoguanine (oxoG). Replicative DNA polymerases misread oxoG residues and insert adenine instead of cytosine opposite the oxidized base. Both bases in the resulting A*oxoG mispair are mutagenic lesions, and both must undergo base-specific replacement to restore the original C*G pair. Doing so represents a formidable challenge to the DNA repair machinery, because adenine makes up roughly 25% of the bases in most genomes. The evolutionarily conserved enzyme adenine DNA glycosylase (called MutY in bacteria and hMYH in humans) initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. A central issue concerning MutY function is the mechanism by which A*oxoG mispairs are targeted among the vast excess of A*T pairs. Here we report the use of disulphide crosslinking to obtain high-resolution crystal structures of MutY-DNA lesion-recognition complexes. These structures reveal the basis for recognizing both lesions in the A*oxoG pair and for catalysing removal of the adenine base.
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The line below this paragraph, {{ABSTRACT_PUBMED_14961129}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14961129 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14961129}}
==About this Structure==
==About this Structure==
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[[Category: Dna repair]]
[[Category: Dna repair]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:50:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:46:54 2008''

Revision as of 00:47, 28 July 2008

Image:1vrl.png

Template:STRUCTURE 1vrl

MutY adenine glycosylase in complex with DNA and soaked adenine free base

Template:ABSTRACT PUBMED 14961129

About this Structure

This structure supersedes the now removed PDB entry 1rrt. Full crystallographic information is available from OCA.

Reference

Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase., Fromme JC, Banerjee A, Huang SJ, Verdine GL, Nature. 2004 Feb 12;427(6975):652-6. PMID:14961129

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