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1wxs

From Proteopedia

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{{STRUCTURE_1wxs| PDB=1wxs | SCENE= }}
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'''Solution Structure of Ufm1, a ubiquitin-fold modifier'''
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===Solution Structure of Ufm1, a ubiquitin-fold modifier===
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==Overview==
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The ubiquitin-fold modifier 1 (Ufm1) is one of various ubiquitin-like modifiers and conjugates to target proteins in cells through Uba5 (E1) and Ufc1 (E2). The Ufm1-system is conserved in metazoa and plants, suggesting its potential roles in various multicellular organisms. Herein, we analyzed the solution structure and dynamics of human Ufm1 (hsUfm1) by nuclear magnetic resonance spectroscopy. Although the global fold of hsUfm1 is similar to those of ubiquitin (Ub) and NEDD8, the cluster of acidic residues conserved in Ub and NEDD8 does not exist on the Ufm1 surface. 15N spin relaxation data revealed that the amino acid residues of hsUfm1 exhibiting conformational fluctuations form a cluster at the C-terminal segment and its spatial proximity, which correspond to the versatile ligand-binding sites of Ub and other ubiquitin-like proteins (Ubls). We suggest that Ub and other Ubl-modifiers share a common feature of potential conformational multiplicity, which might be associated with the broad ligand specificities of these proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 16527251 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16527251}}
==About this Structure==
==About this Structure==
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1WXS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXS OCA].
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1WXS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXS OCA].
==Reference==
==Reference==
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[[Category: Yamaguchi, Y.]]
[[Category: Yamaguchi, Y.]]
[[Category: Ubiquitin-fold]]
[[Category: Ubiquitin-fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:16:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:49:02 2008''

Revision as of 00:49, 28 July 2008

Image:1wxs.png

Template:STRUCTURE 1wxs

Solution Structure of Ufm1, a ubiquitin-fold modifier

Template:ABSTRACT PUBMED 16527251

About this Structure

1WXS is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure and dynamics of Ufm1, a ubiquitin-fold modifier 1., Sasakawa H, Sakata E, Yamaguchi Y, Komatsu M, Tatsumi K, Kominami E, Tanaka K, Kato K, Biochem Biophys Res Commun. 2006 Apr 28;343(1):21-6. Epub 2006 Feb 28. PMID:16527251

Page seeded by OCA on Mon Jul 28 03:49:02 2008

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