243d

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{{STRUCTURE_243d| PDB=243d | SCENE= }}
{{STRUCTURE_243d| PDB=243d | SCENE= }}
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'''STRUCTURE OF THE DNA OCTANUCLEOTIDE D(ACGTACGT)2'''
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===STRUCTURE OF THE DNA OCTANUCLEOTIDE D(ACGTACGT)2===
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==Overview==
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d(ACGTACGT), C(78)H(84)N(30)O(32)P(7).20H(2)O, M(r) (DNA) = 2170, tetragonal, P4(3)2(1)2 (No 96), a = 42.845 (1), b = 42.845(1), c = 24.804 (1) A, V = 45532.5 (2) A(3), z = 8,lambda(MoKalpha) = 0.71069 A, micro (MoKalpha) = 0.10 mm(-1), T = 295 K, R = 0.18 for 1994 unique reflections between 5.0 and 1.9 A resolution. The self-complementary octanucleotide d(ACGTACGT)(2) has been crystallized and its structure determined to a resolution of 1.9 A. The asymmetric unit consists of a single strand of octamer with 20 water molecules. It is only the second example of an octanucleotide having terminal A.T base pairs whose structure has been determined by X-ray crystallography. The sequence adopts the modified A-type conformation found for all octanucleotide duplexes studied to date with the helix bent by approximately 15 degrees and an average tilt angle of 0 degrees. Unusually the data collection was carried out using a 3 kW molybdenum sealed-tube source. The conformational details are discussed in comparison with other closely related sequences.
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(as it appears on PubMed at http://www.pubmed.gov), where 15299669 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15299669}}
==About this Structure==
==About this Structure==
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[[Category: A-dna]]
[[Category: A-dna]]
[[Category: Double helix]]
[[Category: Double helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:22:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:49:12 2008''

Revision as of 00:49, 28 July 2008

Image:243d.png

Template:STRUCTURE 243d

STRUCTURE OF THE DNA OCTANUCLEOTIDE D(ACGTACGT)2

Template:ABSTRACT PUBMED 15299669

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of the DNA octanucleotide d(ACGTACGT)2., Wilcock DJ, Adams A, Cardin CJ, Wakelin LP, Acta Crystallogr D Biol Crystallogr. 1996 May 1;52(Pt 3):481-5. PMID:15299669

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