2bob

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[[Image:2bob.gif|left|200px]]
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{{STRUCTURE_2bob| PDB=2bob | SCENE= }}
{{STRUCTURE_2bob| PDB=2bob | SCENE= }}
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'''POTASSIUM CHANNEL KCSA-FAB COMPLEX IN THALLIUM WITH TETRABUTYLAMMONIUM (TBA)'''
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===POTASSIUM CHANNEL KCSA-FAB COMPLEX IN THALLIUM WITH TETRABUTYLAMMONIUM (TBA)===
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==Overview==
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Potassium channels catalyze the selective transfer of potassium across the cell membrane and are essential for setting the resting potential in cells, controlling heart rate and modulating the firing pattern in neurons. Tetraethylammonium (TEA) blocks ion conduction through potassium channels in a voltage-dependent manner from both sides of the membrane. Here we show the structural basis of TEA blockade by cocrystallizing the prokaryotic potassium channel KcsA with two selective TEA analogs. TEA binding at both sites alters ion occupancy in the selectivity filter; these findings underlie the mutual destabilization and voltage-dependence of TEA blockade. We propose that TEA blocks potassium channels by acting as a potassium analog at the dehydration transition step during permeation.
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(as it appears on PubMed at http://www.pubmed.gov), where 15852022 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15852022}}
==About this Structure==
==About this Structure==
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[[Category: Potassium channel]]
[[Category: Potassium channel]]
[[Category: Protein-antibody fab complex]]
[[Category: Protein-antibody fab complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:34:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:50:20 2008''

Revision as of 00:50, 28 July 2008

Image:2bob.png

Template:STRUCTURE 2bob

POTASSIUM CHANNEL KCSA-FAB COMPLEX IN THALLIUM WITH TETRABUTYLAMMONIUM (TBA)

Template:ABSTRACT PUBMED 15852022

About this Structure

2BOB is a Protein complex structure of sequences from Mus musculus and Streptomyces lividans. Full crystallographic information is available from OCA.

Reference

Structural basis of TEA blockade in a model potassium channel., Lenaeus MJ, Vamvouka M, Focia PJ, Gross A, Nat Struct Mol Biol. 2005 May;12(5):454-9. Epub 2005 Apr 24. PMID:15852022

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