1qrz

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[[Image:1qrz.gif|left|200px]]
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{{STRUCTURE_1qrz| PDB=1qrz | SCENE= }}
{{STRUCTURE_1qrz| PDB=1qrz | SCENE= }}
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'''CATALYTIC DOMAIN OF PLASMINOGEN'''
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===CATALYTIC DOMAIN OF PLASMINOGEN===
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==Overview==
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We have solved the X-ray crystal structure of the proenzyme form of the catalytic domain of plasminogen, with the nonessential mutations M585Q, V673M, and M788L, to 2.0 A resolution. The structure presents an inactive protease characterized by Asp740 (chymotrypsinogen 194) hydrogen bonded to His586 (chymotrypsinogen 40), preventing proper formation of the oxyanion hole and S1 specificity pocket. In addition, the catalytic triad residues are misplaced relative to the active conformation adopted by serine proteases in the chymotrypsin family. Finally, a unique form of zymogen inactivation is observed, characterized by a "foot-in-mouth" mechanism in which Trp761 (chymotrypsinogen 215) is folded into the S1 specificity pocket preventing substrate binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 10460175 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10460175}}
==About this Structure==
==About this Structure==
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Zymogen]]
[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:38:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:52:43 2008''

Revision as of 00:52, 28 July 2008

Image:1qrz.png

Template:STRUCTURE 1qrz

CATALYTIC DOMAIN OF PLASMINOGEN

Template:ABSTRACT PUBMED 10460175

About this Structure

1QRZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the proenzyme domain of plasminogen., Peisach E, Wang J, de los Santos T, Reich E, Ringe D, Biochemistry. 1999 Aug 24;38(34):11180-8. PMID:10460175

Page seeded by OCA on Mon Jul 28 03:52:43 2008

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