2bj6

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[[Image:2bj6.gif|left|200px]]
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{{STRUCTURE_2bj6| PDB=2bj6 | SCENE= }}
{{STRUCTURE_2bj6| PDB=2bj6 | SCENE= }}
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'''CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID'''
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===CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID===
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==Overview==
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The crystal structure of a decameric HNA/RNA (HNA = 2',3'-dideoxy-1',5'-anhydro-d-arabinohexitol nucleic acid) hybrid with the RNA sequence 5'-GGCAUUACGG-3' is the first crystal structure of a hybrid duplex between a naturally occurring nucleic acid and a strand, which is fully modified to contain a six-membered ring instead of ribose. The presence of four duplex helices in the asymmetric unit allows for a detailed discussion of hydration, which revealed a tighter spinelike backbone hydration for the HNA- than for the RNA-strands. The reinforced backbone hydration is suggested to contribute significantly to the exceptional stability of HNA-containing duplexes and might be one of the causes for the evolutionary preference for ribose-derived nucleic acids.
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(as it appears on PubMed at http://www.pubmed.gov), where 15740130 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15740130}}
==About this Structure==
==About this Structure==
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[[Category: Backbone modification]]
[[Category: Backbone modification]]
[[Category: Dna,rna,hna,hexitol nucleic acid,hybrid,duplex,modified nucleic acid,antisense]]
[[Category: Dna,rna,hna,hexitol nucleic acid,hybrid,duplex,modified nucleic acid,antisense]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:21:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:56:20 2008''

Revision as of 00:56, 28 July 2008

Image:2bj6.png

Template:STRUCTURE 2bj6

CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID

Template:ABSTRACT PUBMED 15740130

About this Structure

2BJ6 is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid., Maier T, Przylas I, Strater N, Herdewijn P, Saenger W, J Am Chem Soc. 2005 Mar 9;127(9):2937-43. PMID:15740130

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