3bk1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3bk1.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:3bk1.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3bk1| PDB=3bk1 | SCENE= }}
{{STRUCTURE_3bk1| PDB=3bk1 | SCENE= }}
-
'''Crystal Structure Analysis of RNase J'''
+
===Crystal Structure Analysis of RNase J===
-
==Overview==
+
<!--
-
The maturation and stability of RNA transcripts is controlled by a combination of endo- and exoRNases. RNase J is unique, as it combines an RNase E-like endoribonucleolytic and a 5'-to-3' exoribonucleolytic activity in a single polypeptide. The structural basis for this dual activity is unknown. Here we report the crystal structures of Thermus thermophilus RNase J and its complex with uridine 5'-monophosphate. A binding pocket coordinating the phosphate and base moieties of the nucleotide in the vicinity of the catalytic center provide a rationale for the 5'-monophosphate-dependent 5'-to-3' exoribonucleolytic activity. We show that this dependence is strict; an initial 5'-PPP transcript cannot be degraded exonucleolytically from the 5'-end. Our results suggest that RNase J might switch promptly from endo- to exonucleolytic mode on the same RNA, a property that has important implications for RNA metabolism in numerous prokaryotic organisms and plant organelles containing RNase J orthologs.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18204464}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18204464 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18204464}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Metallo-beta-lactamase]]
[[Category: Metallo-beta-lactamase]]
[[Category: Rnase j]]
[[Category: Rnase j]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:52:09 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:56:20 2008''

Revision as of 00:56, 28 July 2008

Image:3bk1.png

Template:STRUCTURE 3bk1

Crystal Structure Analysis of RNase J

Template:ABSTRACT PUBMED 18204464

About this Structure

3BK1 is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Structural insights into the dual activity of RNase J., de la Sierra-Gallay IL, Zig L, Jamalli A, Putzer H, Nat Struct Mol Biol. 2008 Feb;15(2):206-12. Epub 2008 Jan 20. PMID:18204464

Page seeded by OCA on Mon Jul 28 03:56:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3bk1"
Personal tools