2j8k

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[[Image:2j8k.gif|left|200px]]
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{{Seed}}
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[[Image:2j8k.png|left|200px]]
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{{STRUCTURE_2j8k| PDB=2j8k | SCENE= }}
{{STRUCTURE_2j8k| PDB=2j8k | SCENE= }}
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'''STRUCTURE OF THE FUSION OF NP275 AND NP276, PENTAPEPTIDE REPEAT PROTEINS FROM NOSTOC PUNCTIFORME'''
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===STRUCTURE OF THE FUSION OF NP275 AND NP276, PENTAPEPTIDE REPEAT PROTEINS FROM NOSTOC PUNCTIFORME===
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==Overview==
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The Nostoc punctiforme genes Np275 and Np276 are two adjacently encoded proteins of 98 and 75 amino acids in length and exhibit sequences composed of tandem pentapeptide repeats. The structures of Np275 and a fusion of Np275 and Np276 were determined to 2.1 and 1.5 A, respectively. The two Nostoc proteins fold as highly symmetric right-handed quadrilateral beta-helices similar to the mycobacterial protein MfpA implicated in fluoroquinolone resistance and DNA gyrase inhibition. The sequence composition of the intervening coding region and the ability to express a fused protein by removing the stop codon for Np275 suggests Np275 and Np276 were recently part of a larger ancestral pentapeptide repeat protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 17384236 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17384236}}
==About this Structure==
==About this Structure==
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[[Category: Right handed quadrilateral beta helix]]
[[Category: Right handed quadrilateral beta helix]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:30:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:57:00 2008''

Revision as of 00:57, 28 July 2008

Image:2j8k.png

Template:STRUCTURE 2j8k

STRUCTURE OF THE FUSION OF NP275 AND NP276, PENTAPEPTIDE REPEAT PROTEINS FROM NOSTOC PUNCTIFORME

Template:ABSTRACT PUBMED 17384236

About this Structure

2J8K is a Single protein structure of sequence from Nostoc punctiforme. Full crystallographic information is available from OCA.

Reference

Structural characterization of the fusion of two pentapeptide repeat proteins, Np275 and Np276, from Nostoc punctiforme: resurrection of an ancestral protein., Vetting MW, Hegde SS, Hazleton KZ, Blanchard JS, Protein Sci. 2007 Apr;16(4):755-60. PMID:17384236

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