1pta

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{{STRUCTURE_1pta| PDB=1pta | SCENE= }}
{{STRUCTURE_1pta| PDB=1pta | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF PHOSPHOTRIESTERASE: AN ENZYME CAPABLE OF DETOXIFYING ORGANOPHOSPHATE NERVE AGENTS'''
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===THREE-DIMENSIONAL STRUCTURE OF PHOSPHOTRIESTERASE: AN ENZYME CAPABLE OF DETOXIFYING ORGANOPHOSPHATE NERVE AGENTS===
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==Overview==
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Organophosphates, such as parathion and paraoxon, constitute the largest class of insecticides currently used in industrialized nations. In addition, many of these compounds are known to inhibit mammalian acetylcholinesterases thereby acting as nerve agents. Consequently, organophosphate-degrading enzymes are of considerable interest in light of their ability to detoxify such compounds. Here we report the three-dimensional structure of such an enzyme, namely, phosphotriesterase, as determined by single crystal X-ray diffraction analysis to 2.1-A resolution. Crystals employed in this investigation belonged to the space group P2(1)2(1)2 with unit cell dimensions of a = 80.3 A, b = 93.4 A, and c = 44.8 A and one molecule per asymmetric unit. The structure was solved by multiple isomorphous replacement with two heavy-atom derivatives and refined to a crystallographic R factor of 18.0%. As observed in various other enzymes, the overall fold of the molecule consists of an alpha/beta barrel with eight strands of parallel beta-pleated sheet. In addition, there are two antiparallel beta-strands at the N-terminus. The molecular model of phosphotriesterase presented here provides the initial structural framework necessary toward understanding the enzyme's broad substrate specificities and its catalytic mechanism.
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(as it appears on PubMed at http://www.pubmed.gov), where 7999757 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7999757}}
==About this Structure==
==About this Structure==
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[[Category: Benning, M.]]
[[Category: Benning, M.]]
[[Category: Holden, H M.]]
[[Category: Holden, H M.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:57:28 2008''

Revision as of 00:57, 28 July 2008

Image:1pta.png

Template:STRUCTURE 1pta

THREE-DIMENSIONAL STRUCTURE OF PHOSPHOTRIESTERASE: AN ENZYME CAPABLE OF DETOXIFYING ORGANOPHOSPHATE NERVE AGENTS

Template:ABSTRACT PUBMED 7999757

About this Structure

1PTA is a Single protein structure of sequence from Brevundimonas diminuta. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of phosphotriesterase: an enzyme capable of detoxifying organophosphate nerve agents., Benning MM, Kuo JM, Raushel FM, Holden HM, Biochemistry. 1994 Dec 20;33(50):15001-7. PMID:7999757

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