2kau

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2kau.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2kau.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2kau| PDB=2kau | SCENE= }}
{{STRUCTURE_2kau| PDB=2kau | SCENE= }}
-
'''THE CRYSTAL STRUCTURE OF UREASE FROM KLEBSIELLA AEROGENES AT 2.2 ANGSTROMS RESOLUTION'''
+
===THE CRYSTAL STRUCTURE OF UREASE FROM KLEBSIELLA AEROGENES AT 2.2 ANGSTROMS RESOLUTION===
-
==Overview==
+
<!--
-
The crystal structure of urease from Klebsiella aerogenes has been determined at 2.2 A resolution and refined to an R factor of 18.2 percent. The enzyme contains four structural domains: three with novel folds playing structural roles, and an (alpha beta)8 barrel domain, which contains the bi-nickel center. The two active site nickels are 3.5 A apart. One nickel ion is coordinated by three ligands (with low occupancy of a fourth ligand) and the second is coordinated by five ligands. A carbamylated lysine provides an oxygen ligand to each nickel, explaining why carbon dioxide is required for the activation of urease apoenzyme. The structure is compatible with a catalytic mechanism whereby urea ligates Ni-1 to complete its tetrahedral coordination and a hydroxide ligand of Ni-2 attacks the carbonyl carbon. A surprisingly high structural similarity between the urease catalytic domain and that of the zinc-dependent adenosine deaminase reveals a remarkable example of active site divergence.
+
The line below this paragraph, {{ABSTRACT_PUBMED_7754395}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 7754395 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_7754395}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Karplus, P A.]]
[[Category: Karplus, P A.]]
[[Category: Nickel metalloenzyme]]
[[Category: Nickel metalloenzyme]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:28:49 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:59:01 2008''

Revision as of 00:59, 28 July 2008

Image:2kau.png

Template:STRUCTURE 2kau

THE CRYSTAL STRUCTURE OF UREASE FROM KLEBSIELLA AEROGENES AT 2.2 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 7754395

About this Structure

2KAU is a Protein complex structure of sequences from Klebsiella aerogenes. Full crystallographic information is available from OCA.

Reference

The crystal structure of urease from Klebsiella aerogenes., Jabri E, Carr MB, Hausinger RP, Karplus PA, Science. 1995 May 19;268(5213):998-1004. PMID:7754395

Page seeded by OCA on Mon Jul 28 03:59:01 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2kau"
Personal tools