2fh5

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{{STRUCTURE_2fh5| PDB=2fh5 | SCENE= }}
{{STRUCTURE_2fh5| PDB=2fh5 | SCENE= }}
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'''The Structure of the Mammalian SRP Receptor'''
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===The Structure of the Mammalian SRP Receptor===
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==Overview==
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The eukaryotic signal recognition particle (SRP) and its receptor (SR) play a central role in co-translational targeting of secretory and membrane proteins to the endoplasmic reticulum. The SR is a heterodimeric complex assembled by the two GTPases SRalpha and SRbeta, which is membrane-anchored. Here we present the 2.45-A structure of mammalian SRbeta in its Mg2+ GTP-bound state in complex with the minimal binding domain of SRalpha termed SRX. SRbeta is a member of the Ras-GTPase superfamily closely related to Arf and Sar1, while SRX belongs to the SNARE-like superfamily with a fold also known as longin domain. SRX binds to the P loop and the switch regions of SRbeta-GTP. The binding mode and structural similarity with other GTPase-effector complexes suggests a co-GAP (GTPase-activating protein) function for SRX. Comparison with the homologous yeast structure and other longin domains reveals a conserved adjustable hydrophobic surface within SRX which is of central importance for the SRbeta-GTP:SRX interface. A helix swap in SRX results in the formation of a dimer in the crystal structure. Based on structural conservation we present the SRbeta-GTP:SRX structure as a prototype for conserved interactions in a variety of GTPase regulated targeting events occurring at endomembranes.
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(as it appears on PubMed at http://www.pubmed.gov), where 16439358 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16439358}}
==About this Structure==
==About this Structure==
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[[Category: Signal recognition particle receptor]]
[[Category: Signal recognition particle receptor]]
[[Category: X-ray structure]]
[[Category: X-ray structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:53:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:03:09 2008''

Revision as of 01:03, 28 July 2008

Image:2fh5.png

Template:STRUCTURE 2fh5

The Structure of the Mammalian SRP Receptor

Template:ABSTRACT PUBMED 16439358

About this Structure

2FH5 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of the mammalian signal recognition particle (SRP) receptor as prototype for the interaction of small GTPases with Longin domains., Schlenker O, Hendricks A, Sinning I, Wild K, J Biol Chem. 2006 Mar 31;281(13):8898-906. Epub 2006 Jan 26. PMID:16439358

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