1ti3

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{{STRUCTURE_1ti3| PDB=1ti3 | SCENE= }}
{{STRUCTURE_1ti3| PDB=1ti3 | SCENE= }}
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'''Solution structure of the Thioredoxin h1 from poplar, a CPPC active site variant'''
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===Solution structure of the Thioredoxin h1 from poplar, a CPPC active site variant===
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==Overview==
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Assignment of heteronuclear and homonuclear multidimensional NMR spectra permits determination of the first three-dimensional solution structure of a higher-plant thioredoxin h. The collection of 1906 distance restraints, 137 TALOS-derived dihedral restraints, and 66 hydrogen bonds was used in the restrained molecular dynamics protocol to calculate the structure of the reduced form of thioredoxin h1 from poplar with an atomic rmsd of 0.60 +/- 0.12 A. This enzyme exhibits an unusual active site with the sequence WCPPC and original properties in terms of stability and specificity. Compared to other known thioredoxin structures, thioredoxin h1 from poplar adopts the classical "Trx fold". Its atypical active site possesses a conformation similar to that of other common thioredoxins but appears to be more rigid. Moreover, the hydrogen bond network, stabilizing the in-core beta-sheet, is tighter than in Chlamydomonas reinhardtii, explaining the difference in thermostability.
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{{ABSTRACT_PUBMED_15697225}}
==About this Structure==
==About this Structure==
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1TI3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Populus_tremula Populus tremula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TI3 OCA].
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1TI3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Populus_tremula Populus tremula]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TI3 OCA].
==Reference==
==Reference==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Thioredoxin]]
[[Category: Thioredoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:08:15 2008''

Revision as of 01:08, 28 July 2008

Image:1ti3.png

Template:STRUCTURE 1ti3

Solution structure of the Thioredoxin h1 from poplar, a CPPC active site variant

Template:ABSTRACT PUBMED 15697225

About this Structure

1TI3 is a Single protein structure of sequence from Populus tremula. Full experimental information is available from OCA.

Reference

Solution structure of a natural CPPC active site variant, the reduced form of thioredoxin h1 from poplar., Coudevylle N, Thureau A, Hemmerlin C, Gelhaye E, Jacquot JP, Cung MT, Biochemistry. 2005 Feb 15;44(6):2001-8. PMID:15697225

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