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1v92

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[[Image:1v92.gif|left|200px]]
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{{STRUCTURE_1v92| PDB=1v92 | SCENE= }}
{{STRUCTURE_1v92| PDB=1v92 | SCENE= }}
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'''Solution structure of the UBA domain from p47, a major cofactor of the AAA ATPase p97'''
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===Solution structure of the UBA domain from p47, a major cofactor of the AAA ATPase p97===
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==Overview==
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p47 is a major adaptor molecule of the cytosolic AAA ATPase p97. The principal role of the p97-p47 complex is in regulation of membrane fusion events. Mono-ubiquitin recognition by p47 has also been shown to be crucial in the p97-p47-mediated Golgi membrane fusion events. Here, we describe the high-resolution solution structures of the N-terminal UBA domain and the central domain (SEP) from p47. The p47 UBA domain has the characteristic three-helix bundle fold and forms a highly stable complex with ubiquitin. We report the interaction surfaces of the two proteins and present a structure for the p47 UBA-ubiquitin complex. The p47 SEP domain adopts a novel fold with a betabetabetaalphaalphabeta secondary structure arrangement, where beta4 pairs in a parallel fashion to beta1. Based on biophysical studies, we demonstrate a clear propensity for the self-association of p47. Furthermore, p97 N binding abolishes p47 self-association, revealing the potential interaction surfaces for recognition of other domains within p97 or the substrate.
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The line below this paragraph, {{ABSTRACT_PUBMED_15029246}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15029246 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15029246}}
==About this Structure==
==About this Structure==
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1V92 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V92 OCA].
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1V92 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V92 OCA].
==Reference==
==Reference==
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[[Category: Zhang, X.]]
[[Category: Zhang, X.]]
[[Category: 3-helix bundle]]
[[Category: 3-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:14:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:08:44 2008''

Revision as of 01:08, 28 July 2008

Image:1v92.png

Template:STRUCTURE 1v92

Solution structure of the UBA domain from p47, a major cofactor of the AAA ATPase p97

Template:ABSTRACT PUBMED 15029246

About this Structure

1V92 is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Structure, dynamics and interactions of p47, a major adaptor of the AAA ATPase, p97., Yuan X, Simpson P, McKeown C, Kondo H, Uchiyama K, Wallis R, Dreveny I, Keetch C, Zhang X, Robinson C, Freemont P, Matthews S, EMBO J. 2004 Apr 7;23(7):1463-73. Epub 2004 Mar 18. PMID:15029246

Page seeded by OCA on Mon Jul 28 04:08:44 2008

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