1mvq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1mvq.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1mvq.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1mvq| PDB=1mvq | SCENE= }}
{{STRUCTURE_1mvq| PDB=1mvq | SCENE= }}
-
'''Cratylia mollis lectin (isoform 1) in complex with methyl-alpha-D-mannose'''
+
===Cratylia mollis lectin (isoform 1) in complex with methyl-alpha-D-mannose===
-
==Overview==
+
<!--
-
Carbohydrate-protein interactions play a key role in many biological processes. Cramoll is a lectin purified from Cratylia mollis seeds that is taxonomically related to concanavalin A (Con A). Although Cramoll and Con A have the same monosaccharide specificity, they have different glycoprotein binding profiles. We report the primary structure of Cramoll, determined by Edman degradation and mass spectrometry and its 1.77 A crystallographic structure and compare it with the three-dimensional structure of Con A in an attempt to understand how differential binding can be achieved by similar or nearly identical structures. We report here that Cramoll consists of 236 residues, with 82% identity with Con A, and that its topological architecture is essentially identical to Con A, because the Calpha positional differences are below 3.5 A. Cramoll and Con A have identical binding sites for MealphaMan, Mn2+, and Ca2+. However, we observed six substitutions in a groove adjacent to the extended binding site and two in the extended binding site that may explain the differences in binding of oligosaccharides and glycoproteins between Cramoll and Con A.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12966038}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12966038 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12966038}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Trapani, S.]]
[[Category: Trapani, S.]]
[[Category: Legume lectin]]
[[Category: Legume lectin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:46:44 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:18:59 2008''

Revision as of 01:19, 28 July 2008

Image:1mvq.png

Template:STRUCTURE 1mvq

Cratylia mollis lectin (isoform 1) in complex with methyl-alpha-D-mannose

Template:ABSTRACT PUBMED 12966038

About this Structure

1MVQ is a Single protein structure of sequence from Cratylia mollis. Full crystallographic information is available from OCA.

Reference

Amino acid sequence and tertiary structure of Cratylia mollis seed lectin., De Souza GA, Oliveira PS, Trapani S, Santos AC, Rosa JC, Laure HJ, Faca VM, Correia MT, Tavares GA, Oliva G, Coelho LC, Greene LJ, Glycobiology. 2003 Dec;13(12):961-72. Epub 2003 Sep 9. PMID:12966038

Page seeded by OCA on Mon Jul 28 04:18:59 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mvq"
Personal tools