2jso

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[[Image:2jso.gif|left|200px]]
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{{Seed}}
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[[Image:2jso.png|left|200px]]
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{{STRUCTURE_2jso| PDB=2jso | SCENE= }}
{{STRUCTURE_2jso| PDB=2jso | SCENE= }}
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'''Antimicrobial resistance protein'''
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===Antimicrobial resistance protein===
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==Overview==
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PmrA/PmrB and PhoP/PhoQ are a pair of two-component systems (TCSs) that allow the Gram-negative bacteria to survive the cationic antimicrobial peptide polymyxin B. The two TCSs are linked by the polymyxin resistance protein, PmrD. The PhoP-activated PmrD protects the phosphorylated response regulator PmrA from dephosphorylation, and promotes the transcription of PmrA-activated genes responsible for polymyxin resistance. PmrD is the first protein identified to mediate the connectivity between two TCSs by protecting the phosphorylated response regulator of the downstream TCS. PmrD shows no homology to proteins with known structures. We present here the solution structure of PmrD from Escherichia coli, the first three-dimensional structure of the PmrD family. Our study provides the structural basis of the novel interacting mechanism of bacterial two-component signal-transduction systems.
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The line below this paragraph, {{ABSTRACT_PUBMED_17686460}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17686460 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17686460}}
==About this Structure==
==About this Structure==
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2JSO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSO OCA].
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2JSO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSO OCA].
==Reference==
==Reference==
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[[Category: Signaling protein]]
[[Category: Signaling protein]]
[[Category: Transcription]]
[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:15:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:21:25 2008''

Revision as of 01:21, 28 July 2008

Image:2jso.png

Template:STRUCTURE 2jso

Antimicrobial resistance protein

Template:ABSTRACT PUBMED 17686460

About this Structure

2JSO is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

First structure of the polymyxin resistance proteins., Fu W, Yang F, Kang X, Zhang X, Li Y, Xia B, Jin C, Biochem Biophys Res Commun. 2007 Oct 5;361(4):1033-7. Epub 2007 Aug 2. PMID:17686460

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