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1szp

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{{STRUCTURE_1szp| PDB=1szp | SCENE= }}
{{STRUCTURE_1szp| PDB=1szp | SCENE= }}
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'''A Crystal Structure of the Rad51 Filament'''
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===A Crystal Structure of the Rad51 Filament===
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==Overview==
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Rad51, the major eukaryotic homologous recombinase, is important for the repair of DNA damage and the maintenance of genomic diversity and stability. The active form of this DNA-dependent ATPase is a helical filament within which the search for homology and strand exchange occurs. Here we present the crystal structure of a Saccharomyces cerevisiae Rad51 filament formed by a gain-of-function mutant. This filament has a longer pitch than that seen in crystals of Rad51's prokaryotic homolog RecA, and places the ATPase site directly at a new interface between protomers. Although the filament exhibits approximate six-fold symmetry, alternate protein-protein interfaces are slightly different, implying that the functional unit of Rad51 within the filament may be a dimer. Additionally, we show that mutation of His352, which lies at this new interface, markedly disrupts DNA binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 15235592 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15235592}}
==About this Structure==
==About this Structure==
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[[Category: Homologous recombination]]
[[Category: Homologous recombination]]
[[Category: Rad51 filament]]
[[Category: Rad51 filament]]
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Revision as of 01:24, 28 July 2008

Image:1szp.png

Template:STRUCTURE 1szp

A Crystal Structure of the Rad51 Filament

Template:ABSTRACT PUBMED 15235592

About this Structure

1SZP is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of a Rad51 filament., Conway AB, Lynch TW, Zhang Y, Fortin GS, Fung CW, Symington LS, Rice PA, Nat Struct Mol Biol. 2004 Aug;11(8):791-6. Epub 2004 Jul 4. PMID:15235592

Page seeded by OCA on Mon Jul 28 04:23:59 2008

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