2nz4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2nz4.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2nz4.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2nz4| PDB=2nz4 | SCENE= }}
{{STRUCTURE_2nz4| PDB=2nz4 | SCENE= }}
-
'''Structural investigation of the GlmS ribozyme bound to its catalytic cofactor'''
+
===Structural investigation of the GlmS ribozyme bound to its catalytic cofactor===
-
==Overview==
+
<!--
-
The GlmS riboswitch is located in the 5'-untranslated region of the gene encoding glucosamine-6-phosphate (GlcN6P) synthetase. The GlmS riboswitch is a ribozyme with activity triggered by binding of the metabolite GlcN6P. Presented here is the structure of the GlmS ribozyme (2.5 A resolution) with GlcN6P bound in the active site. The GlmS ribozyme adopts a compact double pseudoknot tertiary structure, with two closely packed helical stacks. Recognition of GlcN6P is achieved through coordination of the phosphate moiety by two hydrated magnesium ions as well as specific nucleobase contacts to the GlcN6P sugar ring. Comparison of this activator bound and the previously published apoenzyme complex supports a model in which GlcN6P does not induce a conformational change in the RNA, as is typical of other riboswitches, but instead functions as a catalytic cofactor for the reaction. This demonstrates that RNA, like protein enzymes, can employ the chemical diversity of small molecules to promote catalytic activity.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17196404}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17196404 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17196404}}
==About this Structure==
==About this Structure==
Line 24: Line 28:
[[Category: Cochrane, J C.]]
[[Category: Cochrane, J C.]]
[[Category: Structural protein/rna]]
[[Category: Structural protein/rna]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:06:16 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:25:06 2008''

Revision as of 01:25, 28 July 2008

Image:2nz4.png

Template:STRUCTURE 2nz4

Structural investigation of the GlmS ribozyme bound to its catalytic cofactor

Template:ABSTRACT PUBMED 17196404

About this Structure

2NZ4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural investigation of the GlmS ribozyme bound to Its catalytic cofactor., Cochrane JC, Lipchock SV, Strobel SA, Chem Biol. 2007 Jan;14(1):97-105. Epub 2006 Dec 28. PMID:17196404

Page seeded by OCA on Mon Jul 28 04:25:06 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2nz4"
Personal tools