1z5a

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[[Image:1z5a.gif|left|200px]]
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{{Seed}}
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[[Image:1z5a.png|left|200px]]
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{{STRUCTURE_1z5a| PDB=1z5a | SCENE= }}
{{STRUCTURE_1z5a| PDB=1z5a | SCENE= }}
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'''Topoisomerase VI-B, ADP-bound dimer form'''
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===Topoisomerase VI-B, ADP-bound dimer form===
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==Overview==
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GHL proteins are functionally diverse enzymes defined by the presence of a conserved ATPase domain that self-associates to trap substrate upon nucleotide binding. The structural states adopted by these enzymes during nucleotide hydrolysis and product release, and their consequences for enzyme catalysis, have remained unclear. Here, we have determined a complete structural map of the ATP turnover cycle for topoVI-B, the ATPase subunit of the archaeal GHL enzyme topoisomerase VI. With this ensemble of structures, we show that significant conformational changes in the subunit occur first upon ATP binding, and subsequently upon release of hydrolyzed P(i). Together, these data provide a structural framework for understanding the role of ATP hydrolysis in the type II topoisomerase reaction. Our results also suggest that the GHL ATPase module is a molecular switch in which ATP hydrolysis serves as a prerequisite but not a driving force for substrate-dependent structural transitions in the enzyme.
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The line below this paragraph, {{ABSTRACT_PUBMED_15939019}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15939019 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15939019}}
==About this Structure==
==About this Structure==
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[[Category: Atpase]]
[[Category: Atpase]]
[[Category: Topoisomerase]]
[[Category: Topoisomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:11:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:35:45 2008''

Revision as of 01:35, 28 July 2008

Image:1z5a.png

Template:STRUCTURE 1z5a

Topoisomerase VI-B, ADP-bound dimer form

Template:ABSTRACT PUBMED 15939019

About this Structure

1Z5A is a Single protein structure of sequence from Sulfolobus shibatae. Full crystallographic information is available from OCA.

Reference

Structural dissection of ATP turnover in the prototypical GHL ATPase TopoVI., Corbett KD, Berger JM, Structure. 2005 Jun;13(6):873-82. PMID:15939019

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