1qnx

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{{Seed}}
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{{STRUCTURE_1qnx| PDB=1qnx | SCENE= }}
{{STRUCTURE_1qnx| PDB=1qnx | SCENE= }}
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'''VES V 5, AN ALLERGEN FROM VESPULA VULGARIS VENOM'''
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===VES V 5, AN ALLERGEN FROM VESPULA VULGARIS VENOM===
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==Overview==
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Ves v 5 is one of three major allergens found in yellow-jacket venom: phospholipase A(1) (Ves v 1), hyaluronidase (Ves v 2), and antigen 5 (Ves v 5). Ves v 5 is related by high amino acid sequence identity to pathogenesis-related proteins including proteins from mammals, reptiles, insects, fungi, and plants. The crystal structure of Ves v 5 has been solved and refined to a resolution of 1.9 A. The majority of residues conserved between the pathogenesis-related proteins can be rationalized in terms of hydrogen bonding patterns and hydrophobic interactions defining an alpha-beta-alpha sandwich core structure. A small number of consensus residues are solvent exposed (including two adjacent histidines) and located in an elongated cavity that forms a putative active site. The site has no structural resemblance to previously characterized enzymes. Homologous antigen 5's from a large number of different yellow jackets, hornets, and paper wasps are known and patients show varying extents of cross-reactivity to the related antigen 5's. The structure of Ves v 5 allows a detailed analysis of the epitopes that may participate in antigenic cross-reactivity, findings that are useful for the development of a vaccine for treatment of insect allergy.
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(as it appears on PubMed at http://www.pubmed.gov), where 11746691 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11746691}}
==About this Structure==
==About this Structure==
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[[Category: Antigen 5]]
[[Category: Antigen 5]]
[[Category: Vespid venom]]
[[Category: Vespid venom]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:30:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:37:28 2008''

Revision as of 01:37, 28 July 2008

Image:1qnx.png

Template:STRUCTURE 1qnx

VES V 5, AN ALLERGEN FROM VESPULA VULGARIS VENOM

Template:ABSTRACT PUBMED 11746691

About this Structure

1QNX is a Single protein structure of sequence from Vespula vulgaris. Full crystallographic information is available from OCA.

Reference

Major venom allergen of yellow jackets, Ves v 5: structural characterization of a pathogenesis-related protein superfamily., Henriksen A, King TP, Mirza O, Monsalve RI, Meno K, Ipsen H, Larsen JN, Gajhede M, Spangfort MD, Proteins. 2001 Dec 1;45(4):438-48. PMID:11746691

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