1lev

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(New page: 200px<br /><applet load="1lev" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lev, resolution 2.15&Aring;" /> '''PORCINE KIDNEY FRUCT...)
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Revision as of 18:24, 20 November 2007

Image:1lev.jpg

1lev, resolution 2.15Å

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PORCINE KIDNEY FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH AN AMP-SITE INHIBITOR

Overview

3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid (MDL-29951), an antagonist of the glycine site of the NMDA receptor, has been found to, be an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase. The, compound binds at the AMP regulatory site by X-ray crystallography. This, represents a new approach to inhibition of fructose 1,6-bisphosphatase and, serves as a lead for further drug design.

About this Structure

1LEV is a Single protein structure of sequence from Sus scrofa with F6P, MN and CLI as ligands. Active as Fructose-bisphosphatase, with EC number 3.1.3.11 Full crystallographic information is available from OCA.

Reference

3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site., Wright SW, Carlo AA, Danley DE, Hageman DL, Karam GA, Mansour MN, McClure LD, Pandit J, Schulte GK, Treadway JL, Wang IK, Bauer PH, Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8. PMID:12781194

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