1t9s

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1t9s.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1t9s.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1t9s| PDB=1t9s | SCENE= }}
{{STRUCTURE_1t9s| PDB=1t9s | SCENE= }}
-
'''Catalytic Domain Of Human Phosphodiesterase 5A in Complex with GMP'''
+
===Catalytic Domain Of Human Phosphodiesterase 5A in Complex with GMP===
-
==Overview==
+
<!--
-
Phosphodiesterases (PDEs) comprise a family of enzymes that modulate the immune response, inflammation, and memory, among many other functions. There are three types of PDEs: cAMP-specific, cGMP-specific, and dual-specific. Here we describe the mechanism of nucleotide selectivity on the basis of high-resolution co-crystal structures of the cAMP-specific PDE4B and PDE4D with AMP, the cGMP-specific PDE5A with GMP, and the apo-structure of the dual-specific PDE1B. These structures show that an invariant glutamine functions as the key specificity determinant by a "glutamine switch" mechanism for recognizing the purine moiety in cAMP or cGMP. The surrounding residues anchor the glutamine residue in different orientations for cAMP and for cGMP. The PDE1B structure shows that in dual-specific PDEs a key histidine residue may enable the invariant glutamine to toggle between cAMP and cGMP. The structural understanding of nucleotide binding enables the design of new PDE inhibitors that may treat diseases in which cyclic nucleotides play a critical role.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15260978}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15260978 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15260978}}
==About this Structure==
==About this Structure==
Line 39: Line 43:
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Pde5a]]
[[Category: Pde5a]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:43:08 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:38:44 2008''

Revision as of 01:38, 28 July 2008

Image:1t9s.png

Template:STRUCTURE 1t9s

Catalytic Domain Of Human Phosphodiesterase 5A in Complex with GMP

Template:ABSTRACT PUBMED 15260978

About this Structure

1T9S is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases., Zhang KY, Card GL, Suzuki Y, Artis DR, Fong D, Gillette S, Hsieh D, Neiman J, West BL, Zhang C, Milburn MV, Kim SH, Schlessinger J, Bollag G, Mol Cell. 2004 Jul 23;15(2):279-86. PMID:15260978

Page seeded by OCA on Mon Jul 28 04:38:44 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1t9s"
Personal tools