2g6w

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{{STRUCTURE_2g6w| PDB=2g6w | SCENE= }}
{{STRUCTURE_2g6w| PDB=2g6w | SCENE= }}
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'''Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine'''
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===Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine===
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==Overview==
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The irreversible inhibition of 8-amino-7-oxononanoate synthase by trifluoroalanine involves decarboxylative defluorination of the inhibitor-PLP aldimine followed by attack of the conjugated imine by the amino group of the active site lysine to afford a covalently bound difluorinated intermediate which can subsequently undergo further HF losses and hydrolysis to afford a 2-(pyridoximine phosphate) acetoyl protein adduct.
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(as it appears on PubMed at http://www.pubmed.gov), where 16557306 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16557306}}
==About this Structure==
==About this Structure==
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[[Category: Plp]]
[[Category: Plp]]
[[Category: Synthase]]
[[Category: Synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:42:54 2008''

Revision as of 01:43, 28 July 2008

Image:2g6w.png

Template:STRUCTURE 2g6w

Suicide inhibition of a-Oxamine Synthase: Structures of the Covalent Adducts of 8-Amino-7-oxonanoate Synthase with trifluoroalanine

Template:ABSTRACT PUBMED 16557306

About this Structure

2G6W is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine., Alexeev D, Baxter RL, Campopiano DJ, Kerbarh O, Sawyer L, Tomczyk N, Watt R, Webster SP, Org Biomol Chem. 2006 Apr 7;4(7):1209-12. Epub 2006 Mar 1. PMID:16557306

Page seeded by OCA on Mon Jul 28 04:42:54 2008

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