1z77

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[[Image:1z77.gif|left|200px]]
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{{STRUCTURE_1z77| PDB=1z77 | SCENE= }}
{{STRUCTURE_1z77| PDB=1z77 | SCENE= }}
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'''Crystal structure of transcriptional regulator protein from Thermotoga maritima.'''
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===Crystal structure of transcriptional regulator protein from Thermotoga maritima.===
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==Overview==
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The crystal structure of a putative transcriptional regulator protein TM1030 from Thermotoga maritima, a hyperthermophilic bacterium, was determined by an unusual multi-wavelength anomalous dispersion method at 2.0 A resolution, in which data from two different crystals and two different beamlines were used. The protein belongs to the tetracycline repressor TetR superfamily. The three-dimensional structure of TM1030 is similar to the structures of proteins that function as multidrug-binding transcriptional repressors, and contains a large solvent-exposed pocket similar to the drug-binding pockets present in those repressors. The asymmetric unit in the crystal structure contains a single protein chain and the twofold symmetry of the dimer is adopted by the crystal symmetry. The structure described in this paper is an apo- form of TM1030. Although it is known that the protein is significantly overexpressed during heat shock, its detailed function cannot be yet explained.
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(as it appears on PubMed at http://www.pubmed.gov), where 17588774 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17588774}}
==About this Structure==
==About this Structure==
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[[Category: Tetr family]]
[[Category: Tetr family]]
[[Category: Transcriptional regulator]]
[[Category: Transcriptional regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:15:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:45:44 2008''

Revision as of 01:45, 28 July 2008

Image:1z77.png

Template:STRUCTURE 1z77

Crystal structure of transcriptional regulator protein from Thermotoga maritima.

Template:ABSTRACT PUBMED 17588774

About this Structure

1Z77 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment., Koclega KD, Chruszcz M, Zimmerman MD, Cymborowski M, Evdokimova E, Minor W, J Struct Biol. 2007 Sep;159(3):424-32. Epub 2007 May 16. PMID:17588774

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