2a6s

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{{STRUCTURE_2a6s| PDB=2a6s | SCENE= }}
{{STRUCTURE_2a6s| PDB=2a6s | SCENE= }}
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'''Crystal structure of YoeB under isopropanol condition'''
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===Crystal structure of YoeB under isopropanol condition===
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==Overview==
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The eubacterial chromosome encodes various addiction modules that control global levels of translation through RNA degradation. Crystal structures of the Escherichia coli YefM2 (antitoxin)-YoeB (toxin) complex and the free YoeB toxin have been determined. The structure of the heterotrimeric complex reveals an asymmetric disorder-to-order recognition strategy, in which one C terminus of the YefM homodimer exclusively interacts with an atypical microbial ribonuclease (RNase) fold of YoeB. Comparison with the YefM-free YoeB structure indicates a conformational rearrangement of the RNase catalytic site of YoeB, induced by interaction with YefM. Complementary biochemical experiments demonstrate that the YoeB toxin has an in vitro RNase activity that preferentially cleaves at the 3' end of purine ribonucleotides.
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(as it appears on PubMed at http://www.pubmed.gov), where 16109374 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16109374}}
==About this Structure==
==About this Structure==
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[[Category: Yefm]]
[[Category: Yefm]]
[[Category: Yoeb]]
[[Category: Yoeb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:46:15 2008''

Revision as of 01:46, 28 July 2008

Image:2a6s.png

Template:STRUCTURE 2a6s

Crystal structure of YoeB under isopropanol condition

Template:ABSTRACT PUBMED 16109374

About this Structure

2A6S is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Conformational change in the catalytic site of the ribonuclease YoeB toxin by YefM antitoxin., Kamada K, Hanaoka F, Mol Cell. 2005 Aug 19;19(4):497-509. PMID:16109374

Page seeded by OCA on Mon Jul 28 04:46:15 2008

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