2jpd

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{{STRUCTURE_2jpd| PDB=2jpd | SCENE= }}
{{STRUCTURE_2jpd| PDB=2jpd | SCENE= }}
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'''Solution structure of the ERCC1 central domain'''
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===Solution structure of the ERCC1 central domain===
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==Overview==
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Human ERCC1/XPF is a structure-specific endonuclease involved in multiple DNA repair pathways. We present the solution structure of the non-catalytic ERCC1 central domain. Although this domain shows structural homology with the catalytically active XPF nuclease domain, functional investigation reveals a completely distinct function for the ERCC1 central domain by performing interactions with both XPA and single-stranded DNA. These interactions are non-competitive and can occur simultaneously through distinct interaction surfaces. Interestingly, the XPA binding by ERCC1 and the catalytic function of XPF are dependent on a structurally homologous region of the two proteins. Although these regions are strictly conserved in each protein family, amino acid composition and surface characteristics are distinct. We discuss the possibility that after XPF gene duplication, the redundant ERCC1 central domain acquired novel functions, thereby increasing the fidelity of eukaryotic DNA repair.
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{{ABSTRACT_PUBMED_17720715}}
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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2JPD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPD OCA].
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2JPD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPD OCA].
==Reference==
==Reference==
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[[Category: Protein]]
[[Category: Protein]]
[[Category: Protein,dna binding protein]]
[[Category: Protein,dna binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:09:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:48:48 2008''

Revision as of 01:48, 28 July 2008

Image:2jpd.png

Template:STRUCTURE 2jpd

Contents

Solution structure of the ERCC1 central domain

Template:ABSTRACT PUBMED 17720715

Disease

Known disease associated with this structure: Cerebrooculofacioskeletal syndrome 4 OMIM:[126380]

About this Structure

2JPD is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Analysis of the XPA and ssDNA-binding surfaces on the central domain of human ERCC1 reveals evidence for subfunctionalization., Tripsianes K, Folkers GE, Zheng C, Das D, Grinstead JS, Kaptein R, Boelens R, Nucleic Acids Res. 2007;35(17):5789-98. Epub 2007 Aug 24. PMID:17720715

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