2spt

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{{STRUCTURE_2spt| PDB=2spt | SCENE= }}
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'''DIFFERENCES IN THE METAL ION STRUCTURE BETWEEN SR-AND CA-PROTHROMBIN FRAGMENT 1'''
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===DIFFERENCES IN THE METAL ION STRUCTURE BETWEEN SR-AND CA-PROTHROMBIN FRAGMENT 1===
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==Overview==
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The structure of Sr-prothrombin fragment 1 has been solved and refined by restrained least-squares methods at 2.5-A resolution to a crystallographic R value of 0.167. The protein structure is very similar to that of Ca-fragment 1. A polymeric array of five Sr2+ ions separated by about 4.0 A is buried among six gamma-carboxyglutamic acid (Gla) residues; three other Sr2+ ions interact with other Gla residues and are located further apart. One of these was not found in the Ca-fragment 1 structure. The coordination of the Sr2+ ions resembles that of Ca2+, but there are some significant differences between them. The most notable is the lack of water coordination with Sr2+ ions and two conformations for Gla 8, which change the coordination of Sr-2 and Sr-3. A hexose moiety of an oligosaccharide was located in the vicinity of Asn101 that was flexibly disordered in Ca-fragment 1. The new Sr2+ ion found may be involved in metal ion phospholipid binding interactions along with Sr-1, and Sr-7, Sr-8.
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(as it appears on PubMed at http://www.pubmed.gov), where 8110739 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8110739}}
==About this Structure==
==About this Structure==
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[[Category: Thrombin]]
[[Category: Thrombin]]
[[Category: Tulinsky, A.]]
[[Category: Tulinsky, A.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:21:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:50:29 2008''

Revision as of 01:50, 28 July 2008

Image:2spt.png

Template:STRUCTURE 2spt

DIFFERENCES IN THE METAL ION STRUCTURE BETWEEN SR-AND CA-PROTHROMBIN FRAGMENT 1

Template:ABSTRACT PUBMED 8110739

About this Structure

2SPT is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Differences in the metal ion structure between Sr- and Ca-prothrombin fragment 1., Seshadri TP, Skrzypczak-Jankun E, Yin M, Tulinsky A, Biochemistry. 1994 Feb 8;33(5):1087-92. PMID:8110739

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