1vzs

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[[Image:1vzs.jpg|left|200px]]
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[[Image:1vzs.png|left|200px]]
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{{STRUCTURE_1vzs| PDB=1vzs | SCENE= }}
{{STRUCTURE_1vzs| PDB=1vzs | SCENE= }}
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'''SOLUTION STRUCTURE OF SUBUNIT F6 FROM THE PERIPHERAL STALK REGION OF ATP SYNTHASE FROM BOVINE HEART MITOCHONDRIA'''
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===SOLUTION STRUCTURE OF SUBUNIT F6 FROM THE PERIPHERAL STALK REGION OF ATP SYNTHASE FROM BOVINE HEART MITOCHONDRIA===
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==Overview==
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The ATP synthase enzyme structure includes two stalk assemblies, the central stalk and the peripheral stalk. Catalysis involves rotation of the central stalk assembly together with the membrane-embedded ring of c-subunits driven by the trans-membrane proton-motive force, while the alpha and beta-subunits of F(1) are prevented from co-rotating by their attachment to the peripheral stalk. In the absence of structures of either the intact peripheral stalk or larger complexes containing it, we are studying its individual components and their interactions to build up an overall picture of its structure. Here, we describe an NMR structural characterisation of F(6), which is a 76-residue protein located in the peripheral stalk of the bovine ATP synthase and is essential for coupling between the proton-motive force and catalysis. Isolated F(6) has a highly flexible structure comprising two helices packed together through a loose hydrophobic core and connected by an unstructured linker. Analysis of chemical shifts, (15)N relaxation and RDC measurements confirm that the F(6) structure is flexible on a wide range of timescales ranging from nanoseconds to seconds. The relationship between this structure for isolated F(6) and its role in the intact peripheral stalk is discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 15327958 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15327958}}
==About this Structure==
==About this Structure==
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1VZS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VZS OCA].
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1VZS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VZS OCA].
==Reference==
==Reference==
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[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Peripheral stalk]]
[[Category: Peripheral stalk]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:57:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:50:37 2008''

Revision as of 01:50, 28 July 2008

Image:1vzs.png

Template:STRUCTURE 1vzs

SOLUTION STRUCTURE OF SUBUNIT F6 FROM THE PERIPHERAL STALK REGION OF ATP SYNTHASE FROM BOVINE HEART MITOCHONDRIA

Template:ABSTRACT PUBMED 15327958

About this Structure

1VZS is a Single protein structure of sequence from Bos taurus. Full experimental information is available from OCA.

Reference

Solution structure of subunit F(6) from the peripheral stalk region of ATP synthase from bovine heart mitochondria., Carbajo RJ, Silvester JA, Runswick MJ, Walker JE, Neuhaus D, J Mol Biol. 2004 Sep 10;342(2):593-603. PMID:15327958

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